Detailed information of TA system TA127454

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 64326..64983
• Replicon: plasmid SA20143792 strain 14[5]12:i:-
• Accession: NZ_CP041027
• Organism: Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain SA20143792

Toxin (Protein)

• Gene name: higB
• Uniprot ID: U3PDC3
• Locus tag: FI669_RS25045
• Protein ID: WP_000270043.1
• Coordinates: 64633..64983 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FI669_RS25040
• Protein ID: WP_000124640.1
• Coordinates: 64326..64628 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FI669_RS24990	59951..60379	+	429	WP_000591074.1	hypothetical protein	-
FI669_RS24995	60436..60795	+	360	WP_000422768.1	hypothetical protein	-
FI669_RS25000	60795..61241	+	447	WP_000919345.1	Fe3+-siderophore ABC transporter permease	-
FI669_RS25005	61238..61756	+	519	WP_000210756.1	nitrite reductase	-
FI669_RS25010	61756..61986	+	231	WP_000972663.1	hypothetical protein	-
FI669_RS25015	61973..62830	+	858	WP_001167032.1	hypothetical protein	-
FI669_RS25025	63061..63588	+	528	WP_001236377.1	thermonuclease family protein	-
FI669_RS25030	63646..63918	+	273	WP_001043047.1	HU family DNA-binding protein	-
FI669_RS25035	64006..64299	+	294	WP_001239997.1	chromosome segregation protein ParM	-
FI669_RS25040	64326..64628	-	303	WP_000124640.1	XRE family transcriptional regulator	Antitoxin
FI669_RS25045	64633..64983	-	351	WP_000270043.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FI669_RS25050	65146..65694	+	549	WP_001061574.1	transcriptional regulator	-
FI669_RS25060	66035..66229	+	195	WP_000343597.1	hypothetical protein	-
FI669_RS25065	66240..66611	+	372	WP_000516916.1	hypothetical protein	-
FI669_RS25070	66604..67074	+	471	WP_001281821.1	hypothetical protein	-
FI669_RS25075	67089..67424	-	336	WP_000683476.1	hypothetical protein	-
FI669_RS25080	67521..68009	+	489	WP_001273096.1	DUF1643 domain-containing protein	-
FI669_RS25085	68012..68509	+	498	WP_000062185.1	hypothetical protein	-
FI669_RS25095	68724..69428	-	705	WP_001067855.1	IS6-like element IS26 family transposase	-
FI669_RS25100	69493..69672	-	180	Protein_92	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..190723	190723

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 17237.68 Da
• Isoelectric Point: 5.5500

>T127454 WP_000270043.1 NZ_CP041027:c64983-64633 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 351 bp

>T127454 NZ_CP041027:c64983-64633 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 14882.85 Da
• Isoelectric Point: 5.5500

>AT127454 WP_000124640.1 NZ_CP041027:c64628-64326 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 303 bp

>AT127454 NZ_CP041027:c64628-64326 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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Structures

Toxin

• AlphaFold DB: A0A7G8AFB9