Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1086505..1087100 Replicon chromosome
Accession NZ_CP041013
Organism Pseudomonas aeruginosa strain FDAARGOS_610

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FIU24_RS05080 Protein ID WP_071534808.1
Coordinates 1086505..1086783 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FIU24_RS05085 Protein ID WP_004352673.1
Coordinates 1086795..1087100 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU24_RS05060 1081931..1083169 + 1239 WP_003113524.1 dipeptidase -
FIU24_RS05065 1083231..1083878 + 648 WP_003095021.1 carbonate dehydratase -
FIU24_RS05070 1083948..1086176 - 2229 WP_004352671.1 TonB-dependent receptor -
FIU24_RS05080 1086505..1086783 + 279 WP_071534808.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FIU24_RS05085 1086795..1087100 + 306 WP_004352673.1 HigA family addiction module antidote protein Antitoxin
FIU24_RS05090 1087607..1088494 + 888 WP_124989691.1 sce7726 family protein -
FIU24_RS05095 1088455..1089369 + 915 WP_124989690.1 sce7725 family protein -
FIU24_RS05100 1089412..1089747 - 336 WP_029528819.1 hypothetical protein -
FIU24_RS05110 1090194..1090466 + 273 WP_003115921.1 hypothetical protein -
FIU24_RS05120 1090678..1090968 + 291 WP_049295997.1 DUF5447 family protein -
FIU24_RS05130 1091506..1091940 + 435 WP_003140508.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10671.25 Da        Isoelectric Point: 8.5576

>T127421 WP_071534808.1 NZ_CP041013:1086505-1086783 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T127421 NZ_CP041013:1086505-1086783 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATGGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11238.80 Da        Isoelectric Point: 4.7769

>AT127421 WP_004352673.1 NZ_CP041013:1086795-1087100 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp

>AT127421 NZ_CP041013:1086795-1087100 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCTGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References