Detailed information of TA system TA127414

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 405996..406333
• Replicon: chromosome
• Accession: NZ_CP041012
• Organism: Enterococcus faecalis strain FDAARGOS_611

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A125WAU0
• Locus tag: FIU23_RS02175
• Protein ID: WP_002391551.1
• Coordinates: 405996..406139 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	406071..406333 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIU23_RS02150	401712..402344	-	633	WP_002358972.1	RloB family protein	-
FIU23_RS02155	402353..403648	-	1296	WP_002371641.1	AAA family ATPase	-
FIU23_RS02170	404110..405726	+	1617	WP_002365430.1	phosphatase PAP2/LCP family protein	-
FIU23_RS02175	405996..406139	+	144	WP_002391551.1	putative holin-like toxin	Toxin
-	406071..406333	-	263	NuclAT_6	-	Antitoxin
-	406283..406332	+	50	NuclAT_7	-	-
FIU23_RS02180	406334..411025	-	4692	WP_002399468.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5175.17 Da
• Isoelectric Point: 8.6389

>T127414 WP_002391551.1 NZ_CP041012:405996-406139 [Enterococcus faecalis]
MNVSTKIYEKRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T127414 NZ_CP041012:405996-406139 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAAGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT127414 NZ_CP041012:c406333-406071 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A125WAU0

Antitoxin