Detailed information of TA system TA127409

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2896839..2897418
• Replicon: chromosome
• Accession: NZ_CP041010
• Organism: Staphylococcus aureus strain FDAARGOS_766

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: FIU19_RS15130
• Protein ID: WP_001025401.1
• Coordinates: 2896839..2897084 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2897053..2897418 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIU19_RS15085	2892165..2893370	-	1206	WP_140045523.1	site-specific integrase	-
FIU19_RS15090	2893496..2894110	+	615	WP_000191464.1	hypothetical protein	-
FIU19_RS15095	2894107..2894253	-	147	WP_001013104.1	hypothetical protein	-
FIU19_RS15100	2894289..2894471	-	183	WP_000705240.1	hypothetical protein	-
FIU19_RS15105	2894541..2895260	-	720	WP_000358224.1	XRE family transcriptional regulator	-
FIU19_RS15110	2895402..2895620	+	219	WP_001198673.1	helix-turn-helix domain-containing protein	-
FIU19_RS15115	2895636..2896412	+	777	WP_140045524.1	Rha family transcriptional regulator	-
FIU19_RS15120	2896441..2896584	+	144	WP_000939498.1	hypothetical protein	-
FIU19_RS15125	2896574..2896783	-	210	WP_000642492.1	hypothetical protein	-
FIU19_RS15130	2896839..2897084	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
FIU19_RS15135	2897053..2897418	-	366	WP_001128433.1	hypothetical protein	Antitoxin
FIU19_RS15140	2897473..2897688	+	216	WP_001036302.1	hypothetical protein	-
FIU19_RS15145	2897713..2897976	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
FIU19_RS15150	2897989..2898150	+	162	WP_001285963.1	DUF1270 family protein	-
FIU19_RS15155	2898229..2898552	+	324	WP_000174994.1	hypothetical protein	-
FIU19_RS15160	2898567..2898929	+	363	WP_000985976.1	hypothetical protein	-
FIU19_RS15165	2898926..2900092	+	1167	WP_000762534.1	DUF2800 domain-containing protein	-
FIU19_RS15170	2900118..2900675	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2892165..2935672	43507

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T127409 WP_001025401.1 NZ_CP041010:2896839-2897084 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T127409 NZ_CP041010:2896839-2897084 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT127409 NZ_CP041010:c2897418-2897053 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin