Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2184439..2184956 Replicon chromosome
Accession NZ_CP041010
Organism Staphylococcus aureus strain FDAARGOS_766

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag FIU19_RS11745 Protein ID WP_000113262.1
Coordinates 2184439..2184705 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag FIU19_RS11750 Protein ID WP_000584499.1
Coordinates 2184705..2184956 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU19_RS11715 2179865..2180401 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
FIU19_RS11720 2180634..2181458 - 825 WP_000572040.1 formate/nitrite transporter family protein -
FIU19_RS11725 2181675..2181857 - 183 WP_000230294.1 hypothetical protein -
FIU19_RS11730 2181941..2182408 - 468 WP_000153344.1 SRPBCC domain-containing protein -
FIU19_RS11735 2182594..2184144 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
FIU19_RS11740 2184333..2184404 - 72 Protein_2165 hypothetical protein -
FIU19_RS11745 2184439..2184705 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
FIU19_RS11750 2184705..2184956 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FIU19_RS11755 2185121..2185222 - 102 WP_001791744.1 hypothetical protein -
FIU19_RS11760 2185229..2185828 - 600 WP_023487174.1 DsbA family protein -
FIU19_RS11765 2185847..2186209 - 363 WP_000819843.1 DUF4467 domain-containing protein -
FIU19_RS11770 2186464..2187714 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
FIU19_RS11775 2187811..2188542 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
FIU19_RS11780 2188539..2189258 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T127405 WP_000113262.1 NZ_CP041010:c2184705-2184439 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T127405 NZ_CP041010:c2184705-2184439 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT127405 WP_000584499.1 NZ_CP041010:c2184956-2184705 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT127405 NZ_CP041010:c2184956-2184705 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References