127384

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 1016899..1017507 Replicon chromosome
Accession NZ_CP041008
Organism Pseudomonas aeruginosa strain FDAARGOS_767

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag FIU18_RS04700 Protein ID WP_003114156.1
Coordinates 1017160..1017507 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag FIU18_RS04695 Protein ID WP_003114155.1
Coordinates 1016899..1017150 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU18_RS04675 1012546..1012902 + 357 WP_003114150.1 DUF2523 domain-containing protein -
FIU18_RS04680 1012906..1014180 + 1275 WP_010895520.1 zonular occludens toxin family protein -
FIU18_RS04685 1014410..1015702 + 1293 WP_003115206.1 hypothetical protein -
FIU18_RS04690 1015702..1016685 + 984 WP_003114154.1 tyrosine-type recombinase/integrase -
FIU18_RS04695 1016899..1017150 + 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FIU18_RS04700 1017160..1017507 + 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FIU18_RS04710 1017834..1018736 - 903 WP_003114157.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
FIU18_RS04715 1019188..1019925 - 738 WP_003114158.1 murein L,D-transpeptidase catalytic domain family protein -
FIU18_RS04720 1020005..1021048 - 1044 WP_003098363.1 L,D-transpeptidase -
FIU18_RS04725 1021184..1021876 - 693 WP_003114159.1 16S rRNA pseudouridine(516) synthase -
FIU18_RS04730 1021876..1022148 - 273 WP_010895521.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1002152..1017507 15355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T127384 WP_003114156.1 NZ_CP041008:1017160-1017507 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T127384 NZ_CP041008:1017160-1017507 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT127384 WP_003114155.1 NZ_CP041008:1016899-1017150 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT127384 NZ_CP041008:1016899-1017150 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References