Detailed information of TA system TA127345

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2328786..2329065
• Replicon: chromosome
• Accession: NZ_CP040998
• Organism: Staphylococcus aureus strain FDAARGOS_773

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: FIU14_RS11650
• Protein ID: WP_001802298.1
• Coordinates: 2328786..2328890 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2328886..2329065 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIU14_RS11625	2324170..2324952	+	783	WP_000908177.1	ABC transporter ATP-binding protein	-
FIU14_RS11630	2325020..2325877	+	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
FIU14_RS11635	2326582..2326674	-	93	WP_001790138.1	hypothetical protein	-
FIU14_RS11640	2326963..2328099	+	1137	WP_000115562.1	SAP domain-containing protein	-
FIU14_RS11645	2328142..2328625	+	484	Protein_2243	recombinase family protein	-
FIU14_RS11650	2328786..2328890	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2328886..2329065	-	180	-	-	Antitoxin
FIU14_RS11655	2329390..2330481	-	1092	WP_000495671.1	lytic regulatory protein	-
FIU14_RS11660	2330747..2331727	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
FIU14_RS11665	2331729..2332049	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
FIU14_RS11670	2332201..2332866	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T127345 WP_001802298.1 NZ_CP040998:2328786-2328890 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T127345 NZ_CP040998:2328786-2328890 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT127345 NZ_CP040998:c2329065-2328886 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGCAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin