Detailed information of TA system TA127341

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2038328..2038512
• Replicon: chromosome
• Accession: NZ_CP040998
• Organism: Staphylococcus aureus strain FDAARGOS_773

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: FIU14_RS10120
• Protein ID: WP_000482650.1
• Coordinates: 2038328..2038435 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2038452..2038512 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIU14_RS10095	2033690..2034163	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
FIU14_RS10100	2034286..2035497	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
FIU14_RS10105	2035679..2036338	-	660	WP_000831298.1	membrane protein	-
FIU14_RS10110	2036398..2037540	-	1143	WP_001176863.1	glycerate kinase	-
FIU14_RS10115	2037808..2038194	+	387	WP_000779358.1	flippase GtxA	-
FIU14_RS10120	2038328..2038435	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2038452..2038512	-	61	-	-	Antitoxin
FIU14_RS10125	2039063..2040826	+	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
FIU14_RS10130	2040851..2042584	+	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
FIU14_RS10135	2042815..2042982	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T127341 WP_000482650.1 NZ_CP040998:2038328-2038435 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T127341 NZ_CP040998:2038328-2038435 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT127341 NZ_CP040998:c2038512-2038452 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin