127338

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 865115..865538 Replicon chromosome
Accession NZ_CP040998
Organism Staphylococcus aureus strain FDAARGOS_773

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FIU14_RS04265 Protein ID WP_001836226.1
Coordinates 865287..865538 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FIU14_RS04260 Protein ID WP_000028421.1
Coordinates 865115..865297 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU14_RS04215 861219..862514 - 1296 WP_001836232.1 PBSX family phage terminase large subunit -
FIU14_RS04220 862517..863011 - 495 WP_001038244.1 terminase small subunit -
FIU14_RS04225 863199..863621 - 423 WP_000162701.1 RinA family phage transcriptional activator -
FIU14_RS04230 863645..863791 - 147 WP_000990005.1 hypothetical protein -
FIU14_RS04235 863792..863965 - 174 WP_001657250.1 transcriptional activator RinB -
FIU14_RS04240 863958..864161 - 204 WP_001072794.1 hypothetical protein -
FIU14_RS04245 864158..864352 - 195 WP_000132920.1 hypothetical protein -
FIU14_RS04250 864349..864555 - 207 WP_000195785.1 DUF1381 domain-containing protein -
FIU14_RS04255 864592..865122 - 531 WP_000185651.1 dUTP pyrophosphatase -
FIU14_RS04260 865115..865297 - 183 WP_000028421.1 hypothetical protein Antitoxin
FIU14_RS04265 865287..865538 - 252 WP_001836226.1 DUF1024 family protein Toxin
FIU14_RS04270 865531..865902 - 372 WP_001557190.1 hypothetical protein -
FIU14_RS04275 865911..866153 - 243 WP_001562543.1 phage protein -
FIU14_RS04280 866157..866513 - 357 WP_000029376.1 hypothetical protein -
FIU14_RS04285 866641..866946 - 306 WP_000101252.1 hypothetical protein -
FIU14_RS04290 866947..867132 - 186 WP_001187243.1 DUF3113 family protein -
FIU14_RS04295 867137..867541 - 405 WP_001836225.1 DUF1064 domain-containing protein -
FIU14_RS04300 867551..867772 - 222 WP_001123695.1 DUF3269 family protein -
FIU14_RS04305 867785..867943 - 159 WP_000256589.1 hypothetical protein -
FIU14_RS04310 867937..868716 - 780 WP_000803062.1 ATP-binding protein -
FIU14_RS04315 868726..869496 - 771 WP_001836222.1 conserved phage C-terminal domain-containing protein -
FIU14_RS04320 869562..869843 + 282 WP_000414755.1 hypothetical protein -
FIU14_RS14175 869836..869985 - 150 WP_001081076.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 835695..880772 45077


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9457.35 Da        Isoelectric Point: 3.8049

>T127338 WP_001836226.1 NZ_CP040998:c865538-865287 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T127338 NZ_CP040998:c865538-865287 [Staphylococcus aureus]
ATGAATAACCGTGAACAAATAGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTTATCTTGATGAAGCAGTAGGGATTATGACGGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6683.59 Da        Isoelectric Point: 4.3791

>AT127338 WP_000028421.1 NZ_CP040998:c865297-865115 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEAQEND

Download         Length: 183 bp

>AT127338 NZ_CP040998:c865297-865115 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References