Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 1984395..1985046 | Replicon | chromosome |
| Accession | NZ_CP040933 | ||
| Organism | Edwardsiella ictaluri strain YCH | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | FGU63_RS09485 | Protein ID | WP_198077054.1 |
| Coordinates | 1984696..1985046 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A2A7U2K2 |
| Locus tag | FGU63_RS09480 | Protein ID | WP_049640646.1 |
| Coordinates | 1984395..1984694 (-) | Length | 100 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FGU63_RS09450 (FGU63_09390) | 1979973..1981313 | - | 1341 | WP_049640648.1 | Fic family protein | - |
| FGU63_RS09455 (FGU63_09395) | 1981442..1982212 | - | 771 | WP_198077052.1 | Rha family transcriptional regulator | - |
| FGU63_RS09460 (FGU63_09400) | 1982619..1982996 | + | 378 | WP_233420345.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FGU63_RS09465 (FGU63_09405) | 1983012..1983293 | + | 282 | WP_278068344.1 | helix-turn-helix transcriptional regulator | - |
| FGU63_RS09470 (FGU63_09410) | 1983544..1983801 | + | 258 | WP_198077053.1 | DUF4160 domain-containing protein | - |
| FGU63_RS09475 (FGU63_09415) | 1983811..1984323 | + | 513 | WP_015871334.1 | DUF2442 domain-containing protein | - |
| FGU63_RS09480 (FGU63_09420) | 1984395..1984694 | - | 300 | WP_049640646.1 | XRE family transcriptional regulator | Antitoxin |
| FGU63_RS09485 (FGU63_09425) | 1984696..1985046 | - | 351 | WP_198077054.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FGU63_RS09490 (FGU63_09430) | 1985096..1985407 | - | 312 | WP_049640644.1 | DUF1364 family protein | - |
| FGU63_RS09495 (FGU63_09435) | 1985410..1986054 | - | 645 | WP_198077055.1 | DUF1367 family protein | - |
| FGU63_RS09500 (FGU63_09440) | 1986164..1986511 | - | 348 | WP_015871339.1 | hypothetical protein | - |
| FGU63_RS09505 (FGU63_09445) | 1986541..1987923 | - | 1383 | WP_049640642.1 | replicative DNA helicase | - |
| FGU63_RS09510 (FGU63_09450) | 1987920..1988870 | - | 951 | WP_198077056.1 | helix-turn-helix domain-containing protein | - |
| FGU63_RS09515 (FGU63_09455) | 1988874..1989062 | - | 189 | WP_198077057.1 | hypothetical protein | - |
| FGU63_RS09520 (FGU63_09460) | 1989072..1989332 | - | 261 | WP_015871343.1 | hypothetical protein | - |
| FGU63_RS09525 (FGU63_09465) | 1989364..1989594 | - | 231 | WP_198077058.1 | porin | - |
| FGU63_RS09530 (FGU63_09470) | 1989591..1989947 | - | 357 | WP_198077059.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1947185..2005180 | 57995 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12907.85 Da Isoelectric Point: 6.9832
>T127310 WP_198077054.1 NZ_CP040933:c1985046-1984696 [Edwardsiella ictaluri]
VWIVETTAAFDEWFTAQSEALQDEMLAALTVLSEFGPNLGRPIVDTLKGAKLANLKELRVQFAGNPIRAFFAFDPERKAI
VLCAGDKTGINEKRFYNSMIKLAEAEFSSHLKKRGS
VWIVETTAAFDEWFTAQSEALQDEMLAALTVLSEFGPNLGRPIVDTLKGAKLANLKELRVQFAGNPIRAFFAFDPERKAI
VLCAGDKTGINEKRFYNSMIKLAEAEFSSHLKKRGS
Download Length: 351 bp
>T127310 NZ_CP040933:c1985046-1984696 [Edwardsiella ictaluri]
GTGTGGATCGTTGAAACGACAGCCGCTTTTGATGAGTGGTTTACGGCACAGAGTGAGGCTTTGCAGGACGAAATGCTGGC
CGCTTTAACCGTATTGAGCGAGTTCGGCCCTAACCTCGGACGCCCTATCGTGGATACGTTAAAGGGTGCAAAGCTGGCAA
ACCTTAAGGAGTTGCGGGTTCAGTTCGCCGGTAATCCGATTCGTGCATTTTTTGCATTCGATCCAGAACGAAAAGCAATT
GTGTTATGCGCTGGCGACAAAACAGGCATCAACGAAAAACGGTTCTATAATTCAATGATTAAGCTTGCTGAGGCTGAATT
CAGTAGTCACCTGAAAAAACGAGGTTCTTAA
GTGTGGATCGTTGAAACGACAGCCGCTTTTGATGAGTGGTTTACGGCACAGAGTGAGGCTTTGCAGGACGAAATGCTGGC
CGCTTTAACCGTATTGAGCGAGTTCGGCCCTAACCTCGGACGCCCTATCGTGGATACGTTAAAGGGTGCAAAGCTGGCAA
ACCTTAAGGAGTTGCGGGTTCAGTTCGCCGGTAATCCGATTCGTGCATTTTTTGCATTCGATCCAGAACGAAAAGCAATT
GTGTTATGCGCTGGCGACAAAACAGGCATCAACGAAAAACGGTTCTATAATTCAATGATTAAGCTTGCTGAGGCTGAATT
CAGTAGTCACCTGAAAAAACGAGGTTCTTAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 11037.74 Da Isoelectric Point: 9.9190
>AT127310 WP_049640646.1 NZ_CP040933:c1984694-1984395 [Edwardsiella ictaluri]
MATLDKLLAQRSPESRAKIEARADELRREVLLHQLREELSMSQSELAAAMGVKQPTVARMEQPDNDPRLSTLKRYVTALG
GQISIDVTLPTGKRVGFHL
MATLDKLLAQRSPESRAKIEARADELRREVLLHQLREELSMSQSELAAAMGVKQPTVARMEQPDNDPRLSTLKRYVTALG
GQISIDVTLPTGKRVGFHL
Download Length: 300 bp
>AT127310 NZ_CP040933:c1984694-1984395 [Edwardsiella ictaluri]
ATGGCAACGCTAGATAAGCTGTTGGCACAGCGTAGTCCTGAAAGTCGCGCGAAAATTGAAGCGCGGGCTGATGAATTGCG
TCGGGAAGTATTGCTCCATCAGCTGAGAGAAGAACTGAGTATGTCACAGAGCGAATTAGCCGCCGCGATGGGGGTAAAAC
AGCCGACAGTGGCAAGAATGGAGCAGCCAGACAACGATCCGCGTTTATCTACGCTTAAACGCTATGTGACCGCCTTGGGC
GGCCAGATAAGTATTGATGTGACGCTACCGACGGGTAAGCGGGTTGGTTTTCACCTCTAA
ATGGCAACGCTAGATAAGCTGTTGGCACAGCGTAGTCCTGAAAGTCGCGCGAAAATTGAAGCGCGGGCTGATGAATTGCG
TCGGGAAGTATTGCTCCATCAGCTGAGAGAAGAACTGAGTATGTCACAGAGCGAATTAGCCGCCGCGATGGGGGTAAAAC
AGCCGACAGTGGCAAGAATGGAGCAGCCAGACAACGATCCGCGTTTATCTACGCTTAAACGCTATGTGACCGCCTTGGGC
GGCCAGATAAGTATTGATGTGACGCTACCGACGGGTAAGCGGGTTGGTTTTCACCTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|