Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1982619..1983293 Replicon chromosome
Accession NZ_CP040933
Organism Edwardsiella ictaluri strain YCH

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FGU63_RS09460 Protein ID WP_233420345.1
Coordinates 1982619..1982996 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FGU63_RS09465 Protein ID WP_278068344.1
Coordinates 1983012..1983293 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU63_RS09425 (FGU63_09365) 1977643..1977990 - 348 WP_035608895.1 phage holin, lambda family -
FGU63_RS09430 (FGU63_09370) 1978074..1978403 - 330 WP_049640650.1 type II toxin-antitoxin system RelE/ParE family toxin -
FGU63_RS09435 (FGU63_09375) 1978378..1978608 - 231 WP_015871327.1 ParD-like family protein -
FGU63_RS09440 (FGU63_09380) 1978740..1978984 - 245 Protein_1814 transposase -
FGU63_RS09445 (FGU63_09385) 1979090..1979908 - 819 WP_198077051.1 hypothetical protein -
FGU63_RS09450 (FGU63_09390) 1979973..1981313 - 1341 WP_049640648.1 Fic family protein -
FGU63_RS09455 (FGU63_09395) 1981442..1982212 - 771 WP_198077052.1 Rha family transcriptional regulator -
FGU63_RS09460 (FGU63_09400) 1982619..1982996 + 378 WP_233420345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGU63_RS09465 (FGU63_09405) 1983012..1983293 + 282 WP_278068344.1 helix-turn-helix transcriptional regulator Antitoxin
FGU63_RS09470 (FGU63_09410) 1983544..1983801 + 258 WP_198077053.1 DUF4160 domain-containing protein -
FGU63_RS09475 (FGU63_09415) 1983811..1984323 + 513 WP_015871334.1 DUF2442 domain-containing protein -
FGU63_RS09480 (FGU63_09420) 1984395..1984694 - 300 WP_049640646.1 XRE family transcriptional regulator -
FGU63_RS09485 (FGU63_09425) 1984696..1985046 - 351 WP_198077054.1 type II toxin-antitoxin system RelE/ParE family toxin -
FGU63_RS09490 (FGU63_09430) 1985096..1985407 - 312 WP_049640644.1 DUF1364 family protein -
FGU63_RS09495 (FGU63_09435) 1985410..1986054 - 645 WP_198077055.1 DUF1367 family protein -
FGU63_RS09500 (FGU63_09440) 1986164..1986511 - 348 WP_015871339.1 hypothetical protein -
FGU63_RS09505 (FGU63_09445) 1986541..1987923 - 1383 WP_049640642.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1947185..2005180 57995


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(32-119)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-85)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14680.05 Da        Isoelectric Point: 10.1221

>T127308 WP_233420345.1 NZ_CP040933:1982619-1982996 [Edwardsiella ictaluri]
MGKNLRKHNNIVMFHSMNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGI
ARVFYCTLTGKRIVMLHSFIKKTQKTPSAERKKAETRMKEVKHGW

Download         Length: 378 bp

>T127308 NZ_CP040933:1982619-1982996 [Edwardsiella ictaluri]
ATGGGCAAGAACTTGCGAAAACATAACAATATTGTTATGTTTCACTCCATGAACTACACTATTGAGTACTACAGCGAAGA
GGTTCGGCTTGAGGTCGATCAGTTGCCAATGGGTATGCGGGTTCGATACCAGCATCTCGTTGAACGCATGGAAATCTACG
GTAGTAATCTCGGAGAACCACACACAAGCCCTTTTGGCGATGGGCTTTTTGAGCTTCGAATCAAAGGCAGTGATGGCATC
GCCCGCGTGTTTTACTGCACTCTTACCGGAAAACGTATCGTCATGCTGCACAGCTTCATCAAGAAAACCCAGAAGACGCC
AAGCGCTGAACGTAAGAAGGCTGAAACCAGAATGAAGGAGGTAAAACATGGCTGGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10267.73 Da        Isoelectric Point: 6.4690

>AT127308 WP_278068344.1 NZ_CP040933:1983012-1983293 [Edwardsiella ictaluri]
MTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKATAITRMESNLASGQSGPSFATLKKF
AHATGKKLQIRFV

Download         Length: 282 bp

>AT127308 NZ_CP040933:1983012-1983293 [Edwardsiella ictaluri]
ATGACGCATGATGAAATGGCTGCAAAATGGATGGAAGACCCGGCATTTAAAGCAGAATACGATGCCATCGAAGAGGAATA
CGCCCTACTCGATGAAATGCTCGCAGCCCGCAAAAACGCGGGGCTGACCCAGGCGCAGGTCGCCGAACGTATGGGAACCA
AGGCTACAGCGATCACTCGCATGGAAAGTAATTTAGCCTCCGGCCAAAGCGGGCCATCATTCGCCACGCTGAAAAAATTT
GCACACGCGACCGGCAAGAAACTGCAGATCCGGTTTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References