Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2545356..2545864 Replicon chromosome
Accession NZ_CP040915
Organism Georgenia sp. Z443

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag FE374_RS11595 Protein ID WP_139929232.1
Coordinates 2545604..2545864 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag FE374_RS11590 Protein ID WP_139929230.1
Coordinates 2545356..2545607 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE374_RS11565 2541577..2542098 + 522 WP_179957312.1 hypothetical protein -
FE374_RS11570 2542022..2543272 - 1251 WP_139929222.1 MFS transporter -
FE374_RS11575 2543334..2543711 + 378 WP_139929224.1 MerR family transcriptional regulator -
FE374_RS11580 2543763..2544560 - 798 WP_139929226.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -
FE374_RS11585 2544694..2545119 - 426 WP_139929228.1 SRPBCC family protein -
FE374_RS11590 2545356..2545607 + 252 WP_139929230.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FE374_RS11595 2545604..2545864 + 261 WP_139929232.1 Txe/YoeB family addiction module toxin Toxin
FE374_RS11600 2546263..2546727 - 465 WP_139929234.1 VapC toxin family PIN domain ribonuclease -
FE374_RS11605 2546714..2546941 - 228 WP_139929236.1 DUF2191 domain-containing protein -
FE374_RS11610 2547569..2548720 - 1152 WP_139931564.1 DUF1524 domain-containing protein -
FE374_RS11615 2549199..2549284 + 86 Protein_2279 DUF3018 family protein -
FE374_RS11620 2549318..2549626 - 309 WP_139929238.1 monooxygenase -
FE374_RS11625 2549770..2550546 + 777 WP_139929239.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10399.90 Da        Isoelectric Point: 9.7747

>T127223 WP_139929232.1 NZ_CP040915:2545604-2545864 [Georgenia sp. Z443]
MRLVWDELAWADYIWWQSEDRRVLKRINLVIKDIARNGNEGLGKPEPLKHGFQGYWSRRITDEHRLVYKTVGEEIRIAAC
RYHYGR

Download         Length: 261 bp

>T127223 NZ_CP040915:2545604-2545864 [Georgenia sp. Z443]
ATGAGGCTCGTCTGGGACGAGCTGGCCTGGGCCGACTACATCTGGTGGCAGTCAGAGGACCGAAGGGTCCTCAAGCGAAT
CAACCTGGTCATCAAGGACATCGCCAGAAACGGCAACGAGGGCCTCGGTAAGCCCGAGCCCCTGAAGCACGGGTTTCAGG
GTTACTGGTCGCGGAGGATCACCGACGAGCACCGGCTGGTCTACAAGACGGTCGGCGAGGAGATCCGCATAGCGGCCTGT
CGATACCACTACGGGCGGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9385.50 Da        Isoelectric Point: 4.5332

>AT127223 WP_139929230.1 NZ_CP040915:2545356-2545607 [Georgenia sp. Z443]
MRTMSYSESRAKYAETLNSVVDNREEVVITRAGHDPVVIVSLDDYESLKETAYLLRSPENARRLLTSIERLEGGAGIVRD
IEE

Download         Length: 252 bp

>AT127223 NZ_CP040915:2545356-2545607 [Georgenia sp. Z443]
ATGCGCACGATGTCCTACTCGGAGTCCCGTGCGAAGTATGCGGAGACGCTCAACTCCGTCGTGGACAACCGCGAGGAAGT
GGTCATTACACGAGCGGGTCACGATCCCGTGGTCATCGTCTCCCTCGACGACTACGAGTCGCTCAAGGAGACCGCCTACC
TCCTCCGCAGTCCCGAGAACGCACGACGCCTGCTGACCTCGATCGAGAGGCTTGAGGGAGGCGCCGGCATCGTCCGGGAC
ATCGAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References