Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 87912..88521 Replicon chromosome
Accession NZ_CP040914
Organism Mesorhizobium sp. 8

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FGU64_RS00450 Protein ID WP_139950456.1
Coordinates 87912..88193 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FGU64_RS00455 Protein ID WP_139950457.1
Coordinates 88225..88521 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU64_RS00435 83674..84420 + 747 WP_136358146.1 cytochrome c biogenesis CcdA family protein -
FGU64_RS00440 84518..85867 + 1350 WP_139950454.1 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU -
FGU64_RS00445 86015..87838 + 1824 WP_139950455.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
FGU64_RS00450 87912..88193 + 282 WP_139950456.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGU64_RS00455 88225..88521 + 297 WP_139950457.1 HigA family addiction module antidote protein Antitoxin
FGU64_RS00460 88599..89351 + 753 WP_139950458.1 DUF502 domain-containing protein -
FGU64_RS00465 89303..91411 - 2109 WP_139950459.1 ATP-dependent DNA helicase RecG -
FGU64_RS00470 91502..91801 + 300 WP_139950460.1 succinate dehydrogenase assembly factor 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10352.75 Da        Isoelectric Point: 9.0512

>T127216 WP_139950456.1 NZ_CP040914:87912-88193 [Mesorhizobium sp. 8]
MIVSYKGKAVEAIAAGKAPKGFPSDLIARTERRLRAVANAADLRDLRSPPGNHLEALKGDRAGQHSIRINEQWRICFRWT
EAGAEDVEIVDYH

Download         Length: 282 bp

>T127216 NZ_CP040914:87912-88193 [Mesorhizobium sp. 8]
ATGATCGTTTCATACAAAGGCAAAGCTGTTGAGGCGATCGCGGCTGGAAAGGCGCCGAAGGGATTTCCGTCGGATTTGAT
TGCCCGCACTGAACGCCGTCTGCGAGCCGTCGCTAATGCAGCAGACTTGAGGGACCTTCGTTCGCCTCCGGGAAATCATC
TCGAGGCTTTGAAAGGGGATCGCGCCGGACAGCATTCTATCCGCATCAACGAGCAATGGCGTATCTGTTTTCGTTGGACG
GAAGCTGGCGCCGAGGACGTGGAGATCGTCGACTATCATTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11332.16 Da        Isoelectric Point: 7.0172

>AT127216 WP_139950457.1 NZ_CP040914:88225-88521 [Mesorhizobium sp. 8]
MLKFARPLHPGEFLREEYLVPLNMSAGALARKLNLPRTRIERIAKEEIGVTPDTALRLARFFDTTPEFWMNFQQAYELET
EARKLASELDKIEPLKAA

Download         Length: 297 bp

>AT127216 NZ_CP040914:88225-88521 [Mesorhizobium sp. 8]
ATGCTTAAATTCGCCCGCCCCCTTCATCCCGGTGAATTCCTCCGCGAGGAATATCTGGTGCCGCTGAACATGAGTGCCGG
AGCATTGGCGCGCAAACTCAATCTGCCACGTACCCGCATCGAGAGAATCGCAAAGGAAGAGATCGGTGTAACGCCCGACA
CGGCCCTGCGGCTGGCTCGGTTTTTTGATACGACCCCCGAATTCTGGATGAATTTCCAGCAAGCTTACGAGTTGGAGACC
GAGGCCCGGAAACTGGCGTCGGAACTCGACAAGATCGAGCCGCTGAAAGCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References