Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 21400..22051 | Replicon | plasmid pAB17H194-2 |
| Accession | NZ_CP040913 | ||
| Organism | Acinetobacter pittii strain AB17H194 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | S3SZA7 |
| Locus tag | E8E07_RS19405 | Protein ID | WP_000269903.1 |
| Coordinates | 21695..22051 (-) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | E8E07_RS19400 | Protein ID | WP_001140619.1 |
| Coordinates | 21400..21702 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E8E07_RS19350 | 16909..17466 | + | 558 | Protein_16 | hypothetical protein | - |
| E8E07_RS19355 | 17490..17714 | + | 225 | WP_005071551.1 | hypothetical protein | - |
| E8E07_RS19360 | 17998..18285 | - | 288 | WP_001258992.1 | helix-turn-helix transcriptional regulator | - |
| E8E07_RS19365 | 18272..18460 | - | 189 | WP_000033474.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| E8E07_RS19370 | 18737..19057 | - | 321 | WP_002123990.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| E8E07_RS19375 | 19242..19630 | + | 389 | Protein_21 | AAA family ATPase | - |
| E8E07_RS19380 | 19558..20103 | + | 546 | Protein_22 | IS5 family transposase | - |
| E8E07_RS19390 | 20861..21088 | + | 228 | WP_005071544.1 | hypothetical protein | - |
| E8E07_RS19395 | 21198..21407 | - | 210 | WP_000069471.1 | hypothetical protein | - |
| E8E07_RS19400 | 21400..21702 | - | 303 | WP_001140619.1 | XRE family transcriptional regulator | Antitoxin |
| E8E07_RS19405 | 21695..22051 | - | 357 | WP_000269903.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| E8E07_RS19410 | 22576..23376 | - | 801 | WP_017398828.1 | hypothetical protein | - |
| E8E07_RS19415 | 23404..23766 | - | 363 | WP_017398829.1 | hypothetical protein | - |
| E8E07_RS19420 | 23974..24336 | - | 363 | Protein_29 | plasmid replication DNA-binding protein | - |
| E8E07_RS19835 | 24744..24839 | - | 96 | Protein_30 | DNA-binding protein | - |
| E8E07_RS19430 | 24837..25007 | - | 171 | Protein_31 | IS3 family transposase | - |
| E8E07_RS19435 | 25183..25467 | - | 285 | WP_005071539.1 | antibiotic biosynthesis monooxygenase | - |
| E8E07_RS19440 | 25487..26485 | - | 999 | WP_005071537.1 | zinc-binding alcohol dehydrogenase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..76962 | 76962 | |
| - | flank | IS/Tn | - | - | 19858..20103 | 245 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13486.45 Da Isoelectric Point: 7.1645
>T127215 WP_000269903.1 NZ_CP040913:c22051-21695 [Acinetobacter pittii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG
Download Length: 357 bp
>T127215 NZ_CP040913:c22051-21695 [Acinetobacter pittii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11206.01 Da Isoelectric Point: 6.7282
>AT127215 WP_001140619.1 NZ_CP040913:c21702-21400 [Acinetobacter pittii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
Download Length: 303 bp
>AT127215 NZ_CP040913:c21702-21400 [Acinetobacter pittii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|