Detailed information of TA system TA127195

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 190871..191208
• Replicon: chromosome
• Accession: NZ_CP040898
• Organism: Enterococcus faecalis strain HA-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: FHO10_RS01320
• Protein ID: WP_002396786.1
• Coordinates: 191065..191208 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	190871..191133 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FHO10_RS01315	186179..190870	+	4692	WP_116491824.1	WxL domain-containing protein	-
-	190871..191133	+	263	-	-	Antitoxin
FHO10_RS01320	191065..191208	-	144	WP_002396786.1	putative holin-like toxin	Toxin
FHO10_RS01325	191540..193156	-	1617	WP_002378864.1	phosphatase PAP2/LCP family protein	-
FHO10_RS01335	193841..194479	+	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
FHO10_RS01340	194646..195638	-	993	WP_002378862.1	biotin--[acetyl-CoA-carboxylase] ligase	-
FHO10_RS01345	195777..195992	+	216	WP_002354768.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T127195 WP_002396786.1 NZ_CP040898:c191208-191065 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T127195 NZ_CP040898:c191208-191065 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT127195 NZ_CP040898:190871-191133 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin