127146

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 69064..69599 Replicon plasmid punnamed
Accession NZ_CP040877
Organism Enterococcus faecium strain HB-1

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag FHP28_RS00360 Protein ID WP_002314366.1
Coordinates 69327..69599 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag FHP28_RS00355 Protein ID WP_002297422.1
Coordinates 69064..69327 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHP28_RS00340 64492..66741 + 2250 WP_002342422.1 alpha-galactosidase -
FHP28_RS00345 66744..67919 + 1176 WP_010728556.1 MFS transporter -
FHP28_RS00350 67922..68830 - 909 Protein_68 IS982 family transposase -
FHP28_RS00355 69064..69327 + 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FHP28_RS00360 69327..69599 + 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
FHP28_RS00365 69676..70005 + 330 WP_002292678.1 AbrB family transcriptional regulator -
FHP28_RS00370 69995..70282 + 288 WP_002300557.1 type II toxin-antitoxin system RelE/ParE family toxin -
FHP28_RS00375 70568..71425 + 858 WP_002292680.1 AAA family ATPase -
FHP28_RS00380 71426..71974 + 549 WP_002292681.1 hypothetical protein -
FHP28_RS00385 72234..73066 + 833 Protein_75 S8 family serine peptidase -
FHP28_RS00390 73139..73819 + 681 WP_136653604.1 IS6 family transposase -
FHP28_RS00395 74071..74337 - 267 WP_025479643.1 hypothetical protein -
FHP28_RS00400 74342..74506 - 165 WP_025477461.1 class II bacteriocin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid ClpL - 1..154417 154417
- inside IScluster/Tn - - 61217..73819 12602


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T127146 WP_002314366.1 NZ_CP040877:69327-69599 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

>T127146 NZ_CP040877:69327-69599 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT127146 WP_002297422.1 NZ_CP040877:69064-69327 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp

>AT127146 NZ_CP040877:69064-69327 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References