Detailed information of TA system TA127138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 822742..823244
• Replicon: chromosome
• Accession: NZ_CP040871
• Organism: Thermomonas sp. SY21

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: FHQ07_RS03930
• Protein ID: WP_139715462.1
• Coordinates: 822742..822996 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: FHQ07_RS03935
• Protein ID: WP_139715380.1
• Coordinates: 822993..823244 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FHQ07_RS03885	818069..818422	+	354	WP_139715448.1	low molecular weight protein tyrosine phosphatase family protein	-
FHQ07_RS03890	818516..819055	+	540	WP_139715450.1	DUF2262 domain-containing protein	-
FHQ07_RS03895	819539..819817	+	279	WP_139715452.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FHQ07_RS03900	819817..820110	+	294	WP_139715453.1	HigA family addiction module antidote protein	-
FHQ07_RS14455	820229..820507	-	279	WP_139715455.1	hypothetical protein	-
FHQ07_RS14460	820867..820974	+	108	WP_206202370.1	excalibur calcium-binding domain-containing protein	-
FHQ07_RS03915	821394..821744	+	351	WP_139715457.1	hypothetical protein	-
FHQ07_RS03920	821908..822204	+	297	WP_139715458.1	hypothetical protein	-
FHQ07_RS03925	822303..822653	+	351	WP_139715460.1	hypothetical protein	-
FHQ07_RS03930	822742..822996	-	255	WP_139715462.1	Txe/YoeB family addiction module toxin	Toxin
FHQ07_RS03935	822993..823244	-	252	WP_139715380.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FHQ07_RS03940	823411..823719	+	309	WP_139715464.1	hypothetical protein	-
FHQ07_RS03945	823826..824161	+	336	WP_139715465.1	hypothetical protein	-
FHQ07_RS03950	824917..825909	-	993	WP_139715466.1	IS30 family transposase	-
FHQ07_RS03955	826107..826529	+	423	WP_139715468.1	hypothetical protein	-
FHQ07_RS03960	826775..826957	+	183	WP_139715470.1	PDZ domain-containing protein	-
FHQ07_RS03965	827377..827886	+	510	WP_139715472.1	2'-5' RNA ligase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	786898..828678	41780
	-	inside	Integron	-	-	759010..827378	68368

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10068.53 Da
• Isoelectric Point: 9.8548

>T127138 WP_139715462.1 NZ_CP040871:c822996-822742 [Thermomonas sp. SY21]
VKLIFSEQAWEDYLYWQKTDKKLVRRINDLIKEITRTPHTGTGKPEPLKHALSGYWSRRINDEHRIVYKAAGDEVLIAQL
RYHY

Nucleotide

• Length: 255 bp

>T127138 NZ_CP040871:c822996-822742 [Thermomonas sp. SY21]
GTGAAGCTCATTTTTTCCGAGCAAGCTTGGGAAGACTACCTGTATTGGCAGAAGACCGATAAGAAGCTGGTGCGGCGGAT
TAACGACCTGATCAAAGAGATCACGAGAACGCCGCATACAGGGACGGGAAAGCCGGAGCCGCTTAAGCATGCGTTATCCG
GCTATTGGTCGAGGCGAATCAATGACGAGCACAGAATCGTCTACAAGGCTGCAGGTGACGAAGTTCTCATTGCACAACTG
CGATACCACTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9244.43 Da
• Isoelectric Point: 4.6127

>AT127138 WP_139715380.1 NZ_CP040871:c823244-822993 [Thermomonas sp. SY21]
MDAITYSTARANLADTMDRVCEDHEPIIITRNGEQAVVMMSLEDFKALEETSYLLRSPKNARRLLESIASLESGNGRARS
LAE

Nucleotide

• Length: 252 bp

>AT127138 NZ_CP040871:c823244-822993 [Thermomonas sp. SY21]
ATGGACGCAATCACCTACAGCACCGCTCGCGCCAATCTGGCCGATACTATGGATCGTGTCTGTGAAGACCACGAGCCGAT
CATCATTACCCGAAATGGTGAGCAGGCGGTGGTGATGATGTCGCTCGAAGACTTCAAGGCGCTCGAGGAGACTTCCTACC
TTCTCAGGAGCCCGAAGAATGCCAGGCGTTTGCTTGAGAGCATTGCCTCGCTTGAATCGGGCAATGGTCGGGCGAGGAGT
CTTGCCGAGTGA