Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 819539..820110 Replicon chromosome
Accession NZ_CP040871
Organism Thermomonas sp. SY21

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FHQ07_RS03895 Protein ID WP_139715452.1
Coordinates 819539..819817 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FHQ07_RS03900 Protein ID WP_139715453.1
Coordinates 819817..820110 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHQ07_RS03860 814625..814882 + 258 WP_139715434.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
FHQ07_RS03865 814870..815190 + 321 WP_139715441.1 type II toxin-antitoxin system RelE/ParE family toxin -
FHQ07_RS03870 816945..817328 + 384 WP_139715443.1 hypothetical protein -
FHQ07_RS03875 817452..817676 + 225 WP_139715445.1 addiction module protein -
FHQ07_RS03880 817676..817972 + 297 WP_139715446.1 type II toxin-antitoxin system RelE/ParE family toxin -
FHQ07_RS03885 818069..818422 + 354 WP_139715448.1 low molecular weight protein tyrosine phosphatase family protein -
FHQ07_RS03890 818516..819055 + 540 WP_139715450.1 DUF2262 domain-containing protein -
FHQ07_RS03895 819539..819817 + 279 WP_139715452.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FHQ07_RS03900 819817..820110 + 294 WP_139715453.1 HigA family addiction module antidote protein Antitoxin
FHQ07_RS14455 820229..820507 - 279 WP_139715455.1 hypothetical protein -
FHQ07_RS14460 820867..820974 + 108 WP_206202370.1 excalibur calcium-binding domain-containing protein -
FHQ07_RS03915 821394..821744 + 351 WP_139715457.1 hypothetical protein -
FHQ07_RS03920 821908..822204 + 297 WP_139715458.1 hypothetical protein -
FHQ07_RS03925 822303..822653 + 351 WP_139715460.1 hypothetical protein -
FHQ07_RS03930 822742..822996 - 255 WP_139715462.1 Txe/YoeB family addiction module toxin -
FHQ07_RS03935 822993..823244 - 252 WP_139715380.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
FHQ07_RS03940 823411..823719 + 309 WP_139715464.1 hypothetical protein -
FHQ07_RS03945 823826..824161 + 336 WP_139715465.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 786898..828678 41780
- inside Integron - - 759010..827378 68368


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10714.12 Da        Isoelectric Point: 9.5056

>T127137 WP_139715452.1 NZ_CP040871:819539-819817 [Thermomonas sp. SY21]
MIKTFRHKGLRRLYETGSTSGVQASHAKRLRLQLTALDTAQSIEDMDIPGFRLHPLKGEMRGRWSITVNGNWRITFEFQD
GNAYVLDYEDYH

Download         Length: 279 bp

>T127137 NZ_CP040871:819539-819817 [Thermomonas sp. SY21]
ATGATCAAGACGTTTCGGCATAAAGGCTTGCGGCGCCTGTACGAGACGGGCAGCACATCAGGCGTACAGGCCAGCCACGC
CAAGCGATTGAGACTGCAATTGACCGCTCTGGATACTGCCCAATCCATTGAAGACATGGACATCCCCGGGTTTCGCCTAC
ATCCCTTGAAAGGCGAAATGCGAGGTCGCTGGTCAATTACCGTCAACGGCAATTGGCGCATCACGTTCGAGTTCCAAGAT
GGGAACGCTTACGTGTTGGACTATGAGGACTACCACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10296.97 Da        Isoelectric Point: 9.9972

>AT127137 WP_139715453.1 NZ_CP040871:819817-820110 [Thermomonas sp. SY21]
MAMHNPPHPGEFIAGIYLEPNGISGRVLAEKLGVAASTLSRVLNGTGRISPEMALRLAKAIGRSPESWLAMQDAHDLWLA
RQSVDLQGVGKLKLAAA

Download         Length: 294 bp

>AT127137 NZ_CP040871:819817-820110 [Thermomonas sp. SY21]
ATGGCTATGCACAACCCTCCTCACCCTGGTGAGTTCATCGCTGGCATCTACCTTGAACCCAATGGGATCAGCGGTCGCGT
ACTGGCGGAAAAGCTCGGCGTTGCGGCCTCTACGCTCAGCCGTGTTCTGAACGGAACCGGTCGTATTTCGCCTGAGATGG
CACTGCGTCTTGCCAAGGCGATCGGTCGCTCTCCCGAGAGCTGGCTCGCCATGCAGGATGCGCATGATCTTTGGCTTGCG
CGCCAGTCCGTTGACCTGCAAGGCGTAGGTAAGCTCAAGCTCGCGGCGGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References