Detailed information of TA system TA127132

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 767747..768249
• Replicon: chromosome
• Accession: NZ_CP040871
• Organism: Thermomonas sp. SY21

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: FHQ07_RS03555
• Protein ID: WP_139715379.1
• Coordinates: 767747..768001 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: FHQ07_RS03560
• Protein ID: WP_139715380.1
• Coordinates: 767998..768249 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FHQ07_RS03530	763218..763640	+	423	WP_139715374.1	hypothetical protein	-
FHQ07_RS03535	764221..764583	+	363	WP_206202345.1	hypothetical protein	-
FHQ07_RS03540	764673..765020	+	348	WP_139715376.1	hypothetical protein	-
FHQ07_RS03545	765948..766841	+	894	WP_206202346.1	hypothetical protein	-
FHQ07_RS03550	767374..767643	+	270	WP_139715378.1	hypothetical protein	-
FHQ07_RS03555	767747..768001	-	255	WP_139715379.1	Txe/YoeB family addiction module toxin	Toxin
FHQ07_RS03560	767998..768249	-	252	WP_139715380.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FHQ07_RS03565	768457..768837	+	381	WP_139715381.1	MAPEG family protein	-
FHQ07_RS03570	769392..769700	+	309	WP_139715382.1	hypothetical protein	-
FHQ07_RS14450	771607..771714	+	108	WP_206202370.1	excalibur calcium-binding domain-containing protein	-
FHQ07_RS03585	771838..772695	+	858	WP_139715383.1	hypothetical protein	-
FHQ07_RS03590	772724..773122	+	399	WP_139715384.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	759010..827378	68368

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10162.66 Da
• Isoelectric Point: 9.8548

>T127132 WP_139715379.1 NZ_CP040871:c768001-767747 [Thermomonas sp. SY21]
VKLIFSEQAWEDYLYWQKTDKKLVRRINDLIKEITRTPHTGTGKPEPLKHALSGYWSRRINDEHRIVYKMAGDEVFIAQL
RYHY

Nucleotide

• Length: 255 bp

>T127132 NZ_CP040871:c768001-767747 [Thermomonas sp. SY21]
GTGAAGCTCATCTTTTCCGAGCAAGCTTGGGAAGACTACCTGTATTGGCAGAAGACCGATAAGAAGCTGGTGCGGCGGAT
TAACGACCTGATCAAAGAGATCACGAGAACGCCGCATACAGGGACGGGAAAGCCGGAGCCGCTTAAGCATGCGTTATCCG
GCTATTGGTCGAGGCGAATCAATGACGAGCACAGAATCGTCTACAAAATGGCGGGTGACGAAGTTTTTATTGCACAACTG
CGATACCACTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9244.43 Da
• Isoelectric Point: 4.6127

>AT127132 WP_139715380.1 NZ_CP040871:c768249-767998 [Thermomonas sp. SY21]
MDAITYSTARANLADTMDRVCEDHEPIIITRNGEQAVVMMSLEDFKALEETSYLLRSPKNARRLLESIASLESGNGRARS
LAE

Nucleotide

• Length: 252 bp

>AT127132 NZ_CP040871:c768249-767998 [Thermomonas sp. SY21]
ATGGACGCAATCACCTACAGCACCGCTCGCGCCAATCTGGCCGATACTATGGATCGTGTCTGTGAAGACCACGAGCCGAT
CATCATTACCCGAAATGGTGAGCAGGCGGTGGTGATGATGTCGCTCGAAGACTTCAAGGCGCTCGAGGAGACTTCCTACC
TTCTCAGGAGCCCGAAGAATGCCAGGCGTTTGCTAGAGAGCATTGCCTCGCTTGAATCGGGCAATGGTCGGGCGAGGAGT
CTTGCCGAGTGA