Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 166372..166625 | Replicon | plasmid pSH12_KPC |
| Accession | NZ_CP040835 | ||
| Organism | Klebsiella pneumoniae strain SH12 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | FHY43_RS29345 | Protein ID | WP_001312851.1 |
| Coordinates | 166476..166625 (+) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 166372..166431 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FHY43_RS29305 (161376) | 161376..162017 | + | 642 | WP_001011939.1 | type A-2 chloramphenicol O-acetyltransferase CatII | - |
| FHY43_RS29310 (162150) | 162150..162854 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| FHY43_RS29315 (162879) | 162879..163079 | + | 201 | WP_072354025.1 | hypothetical protein | - |
| FHY43_RS29320 (163099) | 163099..163845 | + | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
| FHY43_RS29325 (163900) | 163900..164460 | + | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
| FHY43_RS29330 (164592) | 164592..164792 | + | 201 | WP_015059022.1 | hypothetical protein | - |
| FHY43_RS29335 (165178) | 165178..165777 | + | 600 | WP_032083981.1 | PIN domain-containing protein | - |
| FHY43_RS29340 (165839) | 165839..166171 | + | 333 | WP_152916585.1 | hypothetical protein | - |
| - (166372) | 166372..166431 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (166372) | 166372..166431 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (166372) | 166372..166431 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (166372) | 166372..166431 | - | 60 | NuclAT_1 | - | Antitoxin |
| FHY43_RS29345 (166476) | 166476..166625 | + | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| FHY43_RS29350 (166909) | 166909..167157 | + | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
| FHY43_RS29780 (167272) | 167272..167456 | + | 185 | Protein_223 | protein CopA/IncA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-65 / fosA3 / blaTEM-1B / rmtB / blaKPC-2 / catA2 | - | 1..167468 | 167468 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T127090 WP_001312851.1 NZ_CP040835:166476-166625 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T127090 NZ_CP040835:166476-166625 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 60 bp
>AT127090 NZ_CP040835:c166431-166372 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
