Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 1157431..1158125 Replicon chromosome
Accession NZ_CP040815
Organism Dickeya zeae strain A5272

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag FGI00_RS05135 Protein ID WP_282577508.1
Coordinates 1157721..1158125 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID -
Locus tag FGI00_RS05130 Protein ID WP_038914491.1
Coordinates 1157431..1157724 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGI00_RS05105 (FGI00_05115) 1152479..1153729 + 1251 WP_248589168.1 esterase FrsA -
FGI00_RS05110 (FGI00_05120) 1153994..1154353 + 360 WP_102802226.1 sigma factor-binding protein Crl -
FGI00_RS05115 (FGI00_05125) 1154481..1155584 + 1104 WP_012885880.1 glutamate 5-kinase -
FGI00_RS05120 (FGI00_05130) 1155595..1156848 + 1254 WP_248589169.1 glutamate-5-semialdehyde dehydrogenase -
FGI00_RS05130 (FGI00_05145) 1157431..1157724 + 294 WP_038914491.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
FGI00_RS05135 (FGI00_05150) 1157721..1158125 + 405 WP_282577508.1 type II toxin-antitoxin system YafO family toxin Toxin
FGI00_RS05140 (FGI00_05155) 1158227..1158493 - 267 WP_248589170.1 helix-turn-helix transcriptional regulator -
FGI00_RS05145 (FGI00_05160) 1158588..1158701 + 114 Protein_993 IS3 family transposase -
FGI00_RS05150 (FGI00_05165) 1158862..1160703 - 1842 WP_248589171.1 TIGR04141 family sporadically distributed protein -
FGI00_RS05155 (FGI00_05175) 1161789..1162997 + 1209 WP_248589172.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(29-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15531.91 Da        Isoelectric Point: 9.2890

>T127030 WP_282577508.1 NZ_CP040815:1157721-1158125 [Dickeya zeae]
MSIRIFKSTLIRQQLSQKELDDLVADFLSYKKEGVLPDTFGRDAPYDDDRTYPLVKKEQVSHIHLADADAPFPKFLRQFK
RTSDQAHLVYCHGASDPNAYLLIIILKPEAHKMARNNNHMHKIGVMAEAFRMKY

Download         Length: 405 bp

>T127030 NZ_CP040815:1157721-1158125 [Dickeya zeae]
ATGAGCATCAGGATTTTCAAATCAACGCTTATCCGCCAGCAATTGAGCCAGAAAGAGCTGGATGATTTAGTGGCGGATTT
TCTGTCGTATAAAAAAGAGGGCGTGTTGCCGGATACCTTTGGCCGTGACGCCCCTTATGATGATGACCGAACCTATCCCC
TGGTGAAAAAAGAGCAGGTGTCGCATATTCATCTTGCTGATGCAGATGCCCCTTTCCCTAAGTTTTTACGCCAGTTCAAG
CGAACCAGCGATCAGGCCCACTTGGTGTACTGCCATGGTGCCAGTGATCCAAATGCCTACCTGCTGATTATCATCCTGAA
ACCCGAAGCGCATAAGATGGCGCGAAATAATAACCACATGCACAAGATAGGTGTGATGGCCGAAGCATTCAGAATGAAGT
ATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10962.41 Da        Isoelectric Point: 4.9062

>AT127030 WP_038914491.1 NZ_CP040815:1157431-1157724 [Dickeya zeae]
MERILAEKSINITELRKNPAKYFIDEPVAVLSNNRPAGYMVSAKVFEELIDLLEEKQGRVHTAARFRPGAERLSEIAQNG
QTLLQNASDKDLTEFSE

Download         Length: 294 bp

>AT127030 NZ_CP040815:1157431-1157724 [Dickeya zeae]
ATGGAACGCATTCTTGCTGAAAAATCTATCAACATCACCGAGTTAAGAAAAAACCCGGCGAAATATTTTATTGATGAACC
GGTTGCCGTTCTCTCCAACAACCGCCCGGCTGGCTACATGGTCAGCGCTAAGGTGTTTGAAGAACTGATCGACCTGTTGG
AAGAGAAGCAGGGCCGGGTGCATACCGCTGCGCGTTTTCGTCCAGGTGCTGAACGGTTAAGCGAGATTGCGCAGAACGGG
CAGACATTACTGCAAAACGCCTCTGACAAGGATCTGACCGAGTTCTCTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References