Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3369449..3370041 Replicon chromosome
Accession NZ_CP040812
Organism Antarcticibacterium flavum strain JB01H24

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FHG64_RS14650 Protein ID WP_139067109.1
Coordinates 3369449..3369730 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FHG64_RS14655 Protein ID WP_139067110.1
Coordinates 3369742..3370041 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHG64_RS14640 3367308..3367679 + 372 WP_139067107.1 four helix bundle protein -
FHG64_RS14645 3367811..3368626 + 816 WP_139067108.1 patatin-like phospholipase family protein -
FHG64_RS14650 3369449..3369730 + 282 WP_139067109.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FHG64_RS14655 3369742..3370041 + 300 WP_139067110.1 HigA family addiction module antidote protein Antitoxin
FHG64_RS14660 3370938..3371546 - 609 WP_139067111.1 hypothetical protein -
FHG64_RS14665 3371957..3373672 - 1716 WP_139067112.1 asparagine synthase (glutamine-hydrolyzing) -
FHG64_RS14670 3373801..3374157 - 357 WP_139067113.1 helix-turn-helix domain-containing protein -
FHG64_RS14675 3374159..3374452 - 294 WP_139067114.1 type II toxin-antitoxin system HigB family toxin -
FHG64_RS14680 3374594..3374821 + 228 WP_139067115.1 TraY domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11035.69 Da        Isoelectric Point: 11.1275

>T127025 WP_139067109.1 NZ_CP040812:3369449-3369730 [Antarcticibacterium flavum]
VIRSFADKEVNKIWFGIQSRKLPANIQNVARRKLRMINNAQNINDLRIPPANHLEKLSGNLEGFHSIRINKQWRIIFKWN
NDNAFEVQIVDYH

Download         Length: 282 bp

>T127025 NZ_CP040812:3369449-3369730 [Antarcticibacterium flavum]
GTGATAAGATCGTTTGCAGATAAAGAAGTTAATAAAATTTGGTTTGGAATTCAGTCACGGAAGCTTCCTGCTAATATTCA
AAATGTAGCCCGGAGAAAATTACGAATGATAAATAATGCTCAAAATATTAATGATCTAAGGATTCCTCCTGCGAACCACC
TGGAAAAACTTAGTGGGAATTTGGAAGGTTTTCATAGCATCAGGATAAATAAACAATGGAGAATAATATTTAAATGGAAT
AATGATAATGCTTTTGAAGTTCAAATTGTAGATTATCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11517.12 Da        Isoelectric Point: 7.0163

>AT127025 WP_139067110.1 NZ_CP040812:3369742-3370041 [Antarcticibacterium flavum]
MTKLNNIHPGEILKEEFLDPLGISAYRLSKETFIPQTRISEIIKRKRRITADTALRLAKYFGTSAKFWLGLQDDYDLEEE
RNSKEKEFDNIKPLDNTAA

Download         Length: 300 bp

>AT127025 NZ_CP040812:3369742-3370041 [Antarcticibacterium flavum]
ATGACCAAATTAAATAACATACATCCAGGCGAAATATTAAAAGAAGAATTTCTGGATCCACTGGGGATTAGCGCTTATAG
ACTTTCGAAAGAAACATTTATTCCTCAGACCCGAATTAGTGAAATAATTAAAAGGAAAAGAAGAATAACAGCAGATACTG
CTCTCCGATTGGCCAAATATTTTGGAACATCGGCTAAATTCTGGTTAGGATTGCAGGATGATTATGATCTTGAAGAAGAA
AGAAATTCCAAGGAAAAGGAATTTGACAACATAAAGCCATTGGATAATACGGCAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References