Detailed information of TA system TA126995

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 659057..659469
• Replicon: chromosome
• Accession: NZ_CP040805
• Organism: Escherichia fergusonii strain EFCF056

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: D8Z79_RS03180
• Protein ID: WP_125401078.1
• Coordinates: 659057..659398 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	659393..659469 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D8Z79_RS03165	655319..656337	-	1019	Protein_607	IS110 family transposase	-
D8Z79_RS03170	656656..656820	+	165	WP_000394281.1	DUF1127 domain-containing protein	-
D8Z79_RS03175	656917..659010	+	2094	WP_125401077.1	DUF262 domain-containing protein	-
D8Z79_RS03180	659057..659398	-	342	WP_125401078.1	endoribonuclease SymE	Toxin
-	659393..659469	+	77	NuclAT_23	-	Antitoxin
-	659393..659469	+	77	NuclAT_23	-	Antitoxin
-	659393..659469	+	77	NuclAT_23	-	Antitoxin
-	659393..659469	+	77	NuclAT_23	-	Antitoxin
-	659393..659469	+	77	NuclAT_24	-	Antitoxin
-	659393..659469	+	77	NuclAT_24	-	Antitoxin
-	659393..659469	+	77	NuclAT_24	-	Antitoxin
-	659393..659469	+	77	NuclAT_24	-	Antitoxin
D8Z79_RS03185	659619..661376	-	1758	WP_125401079.1	restriction endonuclease subunit S	-
D8Z79_RS03190	661376..662845	-	1470	Protein_612	N-6 DNA methylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	655543..656337	794

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12352.25 Da
• Isoelectric Point: 9.0982

>T126995 WP_125401078.1 NZ_CP040805:c659398-659057 [Escherichia fergusonii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEVAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRKVCKLSARKQKQVREFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T126995 NZ_CP040805:c659398-659057 [Escherichia fergusonii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGCCGCTACCCGGATTACAGCCGTATTCCCGCCATCACTCTGAAAGGTCAGTGGCTGGAAGTCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTGCGAAAGGTGTGCAAGCTGTCGGCACGTAAACAAAAGCAGGTGCGGGAATTTATTGGGGTGATTGC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT126995 NZ_CP040805:659393-659469 [Escherichia fergusonii]
AGTCATGATTACTATTCTCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin