Detailed information of TA system TA126992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-couple_hipB
• Location: 933974..934631
• Replicon: chromosome
• Accession: NZ_CP040804
• Organism: Streptococcus salivarius strain LAB813

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A5C1JKZ1
• Locus tag: FHI56_RS05845
• Protein ID: WP_045001823.1
• Coordinates: 933974..934327 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FHI56_RS05850
• Protein ID: WP_014633320.1
• Coordinates: 934329..934631 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FHI56_RS05820	929628..930017	-	390	WP_045769008.1	hypothetical protein	-
FHI56_RS05825	930169..931011	+	843	WP_045768903.1	Cof-type HAD-IIB family hydrolase	-
FHI56_RS05830	931048..931674	-	627	WP_045768902.1	Pr6Pr family membrane protein	-
FHI56_RS05835	931784..932941	+	1158	WP_149561516.1	DUF2974 domain-containing protein	-
FHI56_RS05840	932973..933737	+	765	WP_149561256.1	SDR family NAD(P)-dependent oxidoreductase	-
FHI56_RS05845	933974..934327	+	354	WP_045001823.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FHI56_RS05850	934329..934631	+	303	WP_014633320.1	helix-turn-helix transcriptional regulator	Antitoxin
FHI56_RS05855	934795..937785	+	2991	WP_149561257.1	type I restriction endonuclease subunit R	-
FHI56_RS05860	937807..938952	+	1146	WP_149561258.1	phage abortive infection protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (35-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-91)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 14056.43 Da
• Isoelectric Point: 10.3788

>T126992 WP_045001823.1 NZ_CP040804:933974-934327 [Streptococcus salivarius]
MYPIHFYKDRNGHEPVREYIETLSINSSKDSRIKLHKIQDYLTMLKNRGTMIGEPFIKHLEGEIWELRPLRDRILFAAWL
DDGFILLHHFVKKTQKTPRRELMKAQKALDDIRKRGL

Nucleotide

• Length: 354 bp

>T126992 NZ_CP040804:933974-934327 [Streptococcus salivarius]
ATGTATCCTATTCATTTTTATAAAGATAGAAATGGACATGAACCTGTTAGAGAGTATATTGAAACATTATCCATAAATTC
AAGCAAAGATTCTAGAATCAAATTACATAAAATTCAAGACTACCTGACTATGTTAAAAAATAGAGGAACCATGATTGGTG
AACCATTCATTAAACATTTGGAAGGAGAGATTTGGGAACTAAGACCCTTAAGAGATAGAATTTTATTTGCAGCATGGCTA
GATGATGGTTTTATTTTGCTTCATCATTTTGTGAAAAAGACACAAAAGACTCCAAGACGTGAGCTGATGAAGGCTCAAAA
AGCTTTAGATGATATTAGAAAGCGAGGATTGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10965.90 Da
• Isoelectric Point: 10.0976

>AT126992 WP_014633320.1 NZ_CP040804:934329-934631 [Streptococcus salivarius]
MAREKNPAIGSSWDDLQKTIFTKEEIAASELRVALMLEIIDARKKQGISQKKLEELSGVKQPVIARMETGKTAPQLDTVL
KILASLGKTLAVVPLDSHVK

Nucleotide

• Length: 303 bp

>AT126992 NZ_CP040804:934329-934631 [Streptococcus salivarius]
ATGGCTCGAGAAAAGAATCCAGCAATTGGAAGTAGTTGGGATGATTTACAGAAAACTATTTTCACTAAAGAGGAAATCGC
GGCAAGTGAACTCCGTGTCGCACTGATGCTTGAGATTATTGATGCTCGTAAAAAACAAGGCATTTCTCAAAAGAAACTTG
AAGAGCTAAGTGGTGTCAAACAACCTGTTATCGCACGTATGGAGACAGGTAAAACAGCACCTCAGTTAGATACGGTTCTT
AAAATACTGGCGAGTCTAGGTAAGACATTGGCGGTAGTCCCACTTGATTCACATGTGAAGTAA

Structures

Toxin

• AlphaFold DB: A0A5C1JKZ1