Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 576885..577397 Replicon chromosome
Accession NZ_CP040804
Organism Streptococcus salivarius strain LAB813

Toxin (Protein)


Gene name yoeB Uniprot ID A0A5C1JJT7
Locus tag FHI56_RS04045 Protein ID WP_070579630.1
Coordinates 577143..577397 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2I1TMD2
Locus tag FHI56_RS04040 Protein ID WP_060971904.1
Coordinates 576885..577139 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHI56_RS04010 572441..572758 + 318 WP_002884193.1 ribosome assembly RNA-binding protein YhbY -
FHI56_RS04015 572866..573498 + 633 WP_037599152.1 nicotinate-nucleotide adenylyltransferase -
FHI56_RS04020 573495..574085 + 591 WP_049529230.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
FHI56_RS04025 574109..574462 + 354 WP_014632696.1 ribosome silencing factor -
FHI56_RS04030 574900..575646 + 747 WP_172633789.1 class I SAM-dependent methyltransferase -
FHI56_RS04035 575652..576743 + 1092 WP_070579632.1 nucleotidyltransferase -
FHI56_RS04040 576885..577139 + 255 WP_060971904.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FHI56_RS04045 577143..577397 + 255 WP_070579630.1 Txe/YoeB family addiction module toxin Toxin
FHI56_RS04050 578122..580227 + 2106 WP_049529235.1 ATP-dependent Clp protease ATP-binding subunit -
FHI56_RS04055 580806..581414 + 609 WP_002884297.1 DUF4230 domain-containing protein -
FHI56_RS11645 581989..582156 + 168 WP_014634940.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10127.61 Da        Isoelectric Point: 8.8499

>T126991 WP_070579630.1 NZ_CP040804:577143-577397 [Streptococcus salivarius]
MLLTFTEDAWMDYCYWQNQDRKTLKRINKLIKDIQRDPFSGIGKPEPLKYDFQGAWSRRIDAENRLIYMVDGKSVAFLSF
KDHY

Download         Length: 255 bp

>T126991 NZ_CP040804:577143-577397 [Streptococcus salivarius]
ATGTTACTCACTTTCACTGAAGATGCATGGATGGATTATTGTTATTGGCAAAATCAGGATAGGAAGACACTTAAGCGAAT
CAATAAGCTGATTAAAGACATTCAACGGGATCCTTTTTCAGGTATTGGGAAACCAGAACCCTTGAAGTATGACTTTCAAG
GAGCTTGGTCTCGACGAATTGATGCTGAAAATCGTTTGATTTATATGGTTGATGGTAAGAGTGTCGCCTTTCTCTCTTTC
AAAGATCATTATTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9719.00 Da        Isoelectric Point: 4.8782

>AT126991 WP_060971904.1 NZ_CP040804:576885-577139 [Streptococcus salivarius]
MEAVVYSTFRNHLKDYMKKVNDEFEPLAVVNKNPDEDIVVVSKSEWDSIQETLRIVQNKELSDKVLRGMAQVRAGETQEH
ALKE

Download         Length: 255 bp

>AT126991 NZ_CP040804:576885-577139 [Streptococcus salivarius]
ATGGAAGCAGTCGTCTATTCAACGTTTCGAAATCATTTAAAGGATTATATGAAAAAGGTTAATGATGAATTTGAACCTCT
AGCTGTAGTCAATAAAAATCCTGATGAAGATATTGTAGTAGTCTCAAAGAGTGAGTGGGATAGCATTCAAGAAACATTGC
GTATTGTTCAAAATAAAGAACTATCAGACAAGGTTTTAAGAGGAATGGCTCAGGTACGTGCTGGAGAGACTCAAGAGCAT
GCACTAAAGGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C1JJT7

Antitoxin

Source ID Structure
AlphaFold DB A0A2I1TMD2

References