Detailed information of TA system TA126987

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2449168..2449352
• Replicon: chromosome
• Accession: NZ_CP040801
• Organism: Staphylococcus aureus strain S15

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: FHD66_RS12060
• Protein ID: WP_000482647.1
• Coordinates: 2449245..2449352 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2449168..2449228 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FHD66_RS12040	2444678..2444845	-	168	WP_031845053.1	hypothetical protein	-
FHD66_RS12045	2445076..2446809	-	1734	WP_000488493.1	ABC transporter ATP-binding protein/permease	-
FHD66_RS12050	2446885..2448597	-	1713	WP_001064821.1	ABC transporter ATP-binding protein/permease	-
FHD66_RS12055	2449051..2449218	-	168	WP_000301893.1	hypothetical protein	-
-	2449168..2449228	+	61	-	-	Antitoxin
FHD66_RS12060	2449245..2449352	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
FHD66_RS12065	2449485..2449871	-	387	WP_000779353.1	flippase GtxA	-
FHD66_RS12070	2450139..2451281	+	1143	WP_001176863.1	glycerate kinase	-
FHD66_RS12075	2451341..2452000	+	660	WP_000831298.1	membrane protein	-
FHD66_RS12080	2452183..2453394	+	1212	WP_001191921.1	multidrug effflux MFS transporter	-
FHD66_RS12085	2453517..2453990	-	474	WP_000456483.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T126987 WP_000482647.1 NZ_CP040801:c2449352-2449245 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T126987 NZ_CP040801:c2449352-2449245 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT126987 NZ_CP040801:2449168-2449228 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin