Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2449168..2449352 Replicon chromosome
Accession NZ_CP040801
Organism Staphylococcus aureus strain S15

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag FHD66_RS12060 Protein ID WP_000482647.1
Coordinates 2449245..2449352 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2449168..2449228 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHD66_RS12040 2444678..2444845 - 168 WP_031845053.1 hypothetical protein -
FHD66_RS12045 2445076..2446809 - 1734 WP_000488493.1 ABC transporter ATP-binding protein/permease -
FHD66_RS12050 2446885..2448597 - 1713 WP_001064821.1 ABC transporter ATP-binding protein/permease -
FHD66_RS12055 2449051..2449218 - 168 WP_000301893.1 hypothetical protein -
- 2449168..2449228 + 61 - - Antitoxin
FHD66_RS12060 2449245..2449352 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
FHD66_RS12065 2449485..2449871 - 387 WP_000779353.1 flippase GtxA -
FHD66_RS12070 2450139..2451281 + 1143 WP_001176863.1 glycerate kinase -
FHD66_RS12075 2451341..2452000 + 660 WP_000831298.1 membrane protein -
FHD66_RS12080 2452183..2453394 + 1212 WP_001191921.1 multidrug effflux MFS transporter -
FHD66_RS12085 2453517..2453990 - 474 WP_000456483.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T126987 WP_000482647.1 NZ_CP040801:c2449352-2449245 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T126987 NZ_CP040801:c2449352-2449245 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT126987 NZ_CP040801:2449168-2449228 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References