Detailed information of TA system TA126984

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2162528..2162745
• Replicon: chromosome
• Accession: NZ_CP040801
• Organism: Staphylococcus aureus strain S15

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: FHD66_RS10580
• Protein ID: WP_001802298.1
• Coordinates: 2162641..2162745 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2162528..2162583 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FHD66_RS10560	2158719..2159384	-	666	WP_001024088.1	SDR family oxidoreductase	-
FHD66_RS10565	2159536..2159856	+	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
FHD66_RS10570	2159858..2160835	+	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
FHD66_RS10575	2161101..2162192	+	1092	WP_000495695.1	hypothetical protein	-
-	2162528..2162583	+	56	-	-	Antitoxin
FHD66_RS10580	2162641..2162745	-	105	WP_001802298.1	hypothetical protein	Toxin
FHD66_RS10585	2162906..2163389	-	484	Protein_2041	recombinase family protein	-
FHD66_RS10590	2163432..2164568	-	1137	Protein_2042	SAP domain-containing protein	-
FHD66_RS10595	2164857..2164949	+	93	WP_031844941.1	hypothetical protein	-
FHD66_RS10600	2165644..2166501	-	858	WP_000370919.1	Cof-type HAD-IIB family hydrolase	-
FHD66_RS10605	2166569..2167351	-	783	WP_000908190.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T126984 WP_001802298.1 NZ_CP040801:c2162745-2162641 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T126984 NZ_CP040801:c2162745-2162641 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT126984 NZ_CP040801:2162528-2162583 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin