Detailed information of TA system TA126980

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 1886111..1886525
• Replicon: chromosome
• Accession: NZ_CP040801
• Organism: Staphylococcus aureus strain S15

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FHD66_RS08980
• Protein ID: WP_001065046.1
• Coordinates: 1886274..1886525 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FHD66_RS08975
• Protein ID: WP_000028424.1
• Coordinates: 1886111..1886284 (-)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FHD66_RS08915	1881645..1881989	-	345	WP_000402904.1	hypothetical protein	-
FHD66_RS08920	1882120..1882419	-	300	WP_031807580.1	HNH endonuclease	-
FHD66_RS08925	1882651..1883067	-	417	WP_000590122.1	hypothetical protein	-
FHD66_RS08930	1883095..1883295	-	201	WP_000265043.1	DUF1514 family protein	-
FHD66_RS08935	1883295..1883945	-	651	WP_001005262.1	hypothetical protein	-
FHD66_RS08940	1884104..1884253	-	150	WP_000595305.1	transcriptional activator RinB	-
FHD66_RS08945	1884250..1884636	-	387	WP_000592201.1	hypothetical protein	-
FHD66_RS08950	1884633..1884839	-	207	WP_000195803.1	DUF1381 domain-containing protein	-
FHD66_RS08955	1884836..1885081	-	246	WP_001282074.1	hypothetical protein	-
FHD66_RS08960	1885118..1885651	-	534	WP_001061838.1	dUTP diphosphatase	-
FHD66_RS08965	1885666..1885827	-	162	WP_000889682.1	hypothetical protein	-
FHD66_RS08970	1885828..1886085	-	258	WP_000248921.1	hypothetical protein	-
FHD66_RS08975	1886111..1886284	-	174	WP_000028424.1	hypothetical protein	Antitoxin
FHD66_RS08980	1886274..1886525	-	252	WP_001065046.1	DUF1024 family protein	Toxin
FHD66_RS08985	1886540..1886782	-	243	WP_000131381.1	phi PVL orf 51-like protein	-
FHD66_RS08990	1886786..1887154	-	369	WP_000101270.1	hypothetical protein	-
FHD66_RS08995	1887167..1887622	-	456	WP_000401965.1	RusA family crossover junction endodeoxyribonuclease	-
FHD66_RS09000	1887631..1887849	-	219	WP_000338528.1	hypothetical protein	-
FHD66_RS09005	1887856..1888740	-	885	WP_158139158.1	DnaD domain protein	-
FHD66_RS09010	1888770..1889240	-	471	WP_096002306.1	single-stranded DNA-binding protein	-
FHD66_RS09015	1889241..1889858	-	618	WP_078065545.1	MBL fold metallo-hydrolase	-
FHD66_RS09020	1889939..1890859	-	921	WP_000138473.1	recombinase RecT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hysA / scn / chp / sak	1845485..1906144	60659

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9377.26 Da
• Isoelectric Point: 3.7128

>T126980 WP_001065046.1 NZ_CP040801:c1886525-1886274 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T126980 NZ_CP040801:c1886525-1886274 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6468.29 Da
• Isoelectric Point: 4.2484

>AT126980 WP_000028424.1 NZ_CP040801:c1886284-1886111 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Nucleotide

• Length: 174 bp

>AT126980 NZ_CP040801:c1886284-1886111 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA