Detailed information of TA system TA126978

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1862507..1862806
• Replicon: chromosome
• Accession: NZ_CP040801
• Organism: Staphylococcus aureus strain S15

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: FHD66_RS08815
• Protein ID: WP_011447039.1
• Coordinates: 1862630..1862806 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1862507..1862562 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FHD66_RS08775	1857838..1858098	+	261	WP_001791826.1	hypothetical protein	-
FHD66_RS08780	1858151..1858501	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
FHD66_RS08785	1859186..1859635	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
FHD66_RS08790	1859730..1860065	-	336	Protein_1726	SH3 domain-containing protein	-
FHD66_RS08795	1860715..1861206	-	492	WP_000919350.1	staphylokinase	-
FHD66_RS08800	1861397..1862152	-	756	WP_000861038.1	CHAP domain-containing protein	-
FHD66_RS08805	1862164..1862418	-	255	WP_000611512.1	phage holin	-
FHD66_RS08810	1862470..1862577	+	108	WP_001791821.1	hypothetical protein	-
-	1862499..1862638	+	140	NuclAT_0	-	-
-	1862499..1862638	+	140	NuclAT_0	-	-
-	1862499..1862638	+	140	NuclAT_0	-	-
-	1862499..1862638	+	140	NuclAT_0	-	-
-	1862507..1862562	+	56	-	-	Antitoxin
FHD66_RS08815	1862630..1862806	-	177	WP_011447039.1	putative holin-like toxin	Toxin
FHD66_RS08820	1862956..1863252	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
FHD66_RS08825	1863310..1863597	-	288	WP_001040261.1	hypothetical protein	-
FHD66_RS08830	1863644..1863796	-	153	WP_001153681.1	hypothetical protein	-
FHD66_RS08835	1863786..1867571	-	3786	WP_189912511.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hysA / scn / chp / sak	1845485..1906144	60659

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T126978 WP_011447039.1 NZ_CP040801:c1862806-1862630 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T126978 NZ_CP040801:c1862806-1862630 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT126978 NZ_CP040801:1862507-1862562 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin