Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 1862499..1862806 Replicon chromosome
Accession NZ_CP040801
Organism Staphylococcus aureus strain S15

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag FHD66_RS08815 Protein ID WP_011447039.1
Coordinates 1862630..1862806 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1862499..1862638 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHD66_RS08775 1857838..1858098 + 261 WP_001791826.1 hypothetical protein -
FHD66_RS08780 1858151..1858501 - 351 WP_000702263.1 complement inhibitor SCIN-A -
FHD66_RS08785 1859186..1859635 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
FHD66_RS08790 1859730..1860065 - 336 Protein_1726 SH3 domain-containing protein -
FHD66_RS08795 1860715..1861206 - 492 WP_000919350.1 staphylokinase -
FHD66_RS08800 1861397..1862152 - 756 WP_000861038.1 CHAP domain-containing protein -
FHD66_RS08805 1862164..1862418 - 255 WP_000611512.1 phage holin -
FHD66_RS08810 1862470..1862577 + 108 WP_001791821.1 hypothetical protein -
- 1862499..1862638 + 140 NuclAT_0 - Antitoxin
- 1862499..1862638 + 140 NuclAT_0 - Antitoxin
- 1862499..1862638 + 140 NuclAT_0 - Antitoxin
- 1862499..1862638 + 140 NuclAT_0 - Antitoxin
FHD66_RS08815 1862630..1862806 - 177 WP_011447039.1 putative holin-like toxin Toxin
FHD66_RS08820 1862956..1863252 - 297 WP_000539688.1 DUF2951 domain-containing protein -
FHD66_RS08825 1863310..1863597 - 288 WP_001040261.1 hypothetical protein -
FHD66_RS08830 1863644..1863796 - 153 WP_001153681.1 hypothetical protein -
FHD66_RS08835 1863786..1867571 - 3786 WP_189912511.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hysA / scn / chp / sak 1845485..1906144 60659


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(30-58)


Sequences


Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T126977 WP_011447039.1 NZ_CP040801:c1862806-1862630 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T126977 NZ_CP040801:c1862806-1862630 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT126977 NZ_CP040801:1862499-1862638 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7NS1


Antitoxin

Download structure file

References