Detailed information of TA system TA126892

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 58802..59054
• Replicon: plasmid p16HN-35_KPC
• Accession: NZ_CP040713
• Organism: Klebsiella pneumoniae strain 16HN-35

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: -
• Locus tag: FGL96_RS28905
• Protein ID: WP_286497435.1
• Coordinates: 58956..59054 (+)
• Length: 33 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	58802..58861 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGL96_RS28870 (54145)	54145..54360	+	216	Protein_76	type IV conjugative transfer system protein TraL	-
FGL96_RS28875 (54380)	54380..54544	+	165	Protein_77	TraE/TraK family type IV conjugative transfer system protein	-
FGL96_RS28880 (54584)	54584..55296	-	713	Protein_78	IS6 family transposase	-
FGL96_RS28885 (55537)	55537..56283	+	747	WP_000205770.1	conjugal transfer pilus acetylase TraX	-
FGL96_RS28890 (56338)	56338..56898	+	561	WP_000139328.1	fertility inhibition protein FinO	-
FGL96_RS28895 (57030)	57030..57230	+	201	WP_015059022.1	hypothetical protein	-
FGL96_RS28900 (57616)	57616..58213	+	598	Protein_82	PIN domain-containing protein	-
- (58802)	58802..58861	-	60	NuclAT_0	-	Antitoxin
- (58802)	58802..58861	-	60	NuclAT_0	-	Antitoxin
- (58802)	58802..58861	-	60	NuclAT_0	-	Antitoxin
- (58802)	58802..58861	-	60	NuclAT_0	-	Antitoxin
FGL96_RS28905 (58956)	58956..59054	+	99	WP_286497435.1	Hok/Gef family protein	Toxin
FGL96_RS28910 (59338)	59338..59586	+	249	WP_000083837.1	replication regulatory protein RepA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	blaCTX-M-65 / blaKPC-2	-	1..59897	59897
	-	flank	IS/Tn	-	-	54967..55296	329

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (1-28)

Sequences

Toxin

Protein

• Length: 33 a.a.
• Molecular weight: 3776.42 Da
• Isoelectric Point: 9.2757

>T126892 WP_286497435.1 NZ_CP040713:58956-59054 [Klebsiella pneumoniae]
VFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 99 bp

>T126892 NZ_CP040713:58956-59054 [Klebsiella pneumoniae]
GTGTTTTCACTGATATTCAGGGAACGGTTATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGC
CTACGAAGCACGGAAGTAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT126892 NZ_CP040713:c58861-58802 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Structures

Antitoxin