Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
Location | 2181623..2182491 | Replicon | chromosome |
Accession | NZ_CP040688 | ||
Organism | Mycobacterium tuberculosis complex sp. N0052 |
Toxin (Protein)
Gene name | higB | Uniprot ID | P9WJA4 |
Locus tag | FF951_RS10180 | Protein ID | WP_010886136.1 |
Coordinates | 2181623..2182000 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | G0TLM0 |
Locus tag | FF951_RS10185 | Protein ID | WP_003409886.1 |
Coordinates | 2182042..2182491 (+) | Length | 150 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FF951_RS10130 (FF951_10460) | 2177412..2177864 | - | 453 | WP_003899095.1 | lipoprotein | - |
FF951_RS10135 (FF951_10465) | 2177928..2178329 | + | 402 | WP_003409869.1 | hypothetical protein | - |
FF951_RS10140 (FF951_10470) | 2178322..2178504 | - | 183 | WP_019250140.1 | hypothetical protein | - |
FF951_RS10145 (FF951_10475) | 2178618..2178968 | - | 351 | WP_003409871.1 | hypothetical protein | - |
FF951_RS10150 (FF951_10480) | 2178979..2179881 | - | 903 | WP_003899097.1 | hypothetical protein | - |
FF951_RS10155 (FF951_10485) | 2179902..2180093 | - | 192 | WP_003409876.1 | hypothetical protein | - |
FF951_RS10160 (FF951_10490) | 2180094..2180390 | - | 297 | WP_003409877.1 | hypothetical protein | - |
FF951_RS10165 (FF951_10495) | 2180630..2180845 | + | 216 | WP_003409878.1 | antitoxin | - |
FF951_RS10170 (FF951_10500) | 2180842..2181153 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
FF951_RS10175 | 2181127..2181648 | - | 522 | WP_003904745.1 | hypothetical protein | - |
FF951_RS10180 (FF951_10510) | 2181623..2182000 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
FF951_RS10185 (FF951_10515) | 2182042..2182491 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
FF951_RS10190 (FF951_10520) | 2182488..2183033 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
FF951_RS10195 (FF951_10525) | 2182922..2183536 | - | 615 | WP_003901296.1 | hypothetical protein | - |
FF951_RS10200 (FF951_10530) | 2183585..2183881 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
FF951_RS10205 (FF951_10535) | 2183878..2184129 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
FF951_RS10210 (FF951_10540) | 2184116..2184610 | + | 495 | WP_003899099.1 | hypothetical protein | - |
FF951_RS10215 (FF951_10545) | 2184770..2185177 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
FF951_RS10220 (FF951_10550) | 2185181..2185453 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
FF951_RS10225 (FF951_10555) | 2185486..2186706 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T126529 WP_010886136.1 NZ_CP040688:2181623-2182000 [Mycobacterium tuberculosis complex sp. N0052]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T126529 NZ_CP040688:2181623-2182000 [Mycobacterium tuberculosis complex sp. N0052]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT126529 WP_003409886.1 NZ_CP040688:2182042-2182491 [Mycobacterium tuberculosis complex sp. N0052]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT126529 NZ_CP040688:2182042-2182491 [Mycobacterium tuberculosis complex sp. N0052]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCATCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCATCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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