Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4631149..4631891 Replicon chromosome
Accession NZ_CP040677
Organism Kosakonia sacchari strain DSM 107661

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FGE25_RS22030 Protein ID WP_045511683.1
Coordinates 4631580..4631891 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FGE25_RS22025 Protein ID WP_045511685.1
Coordinates 4631149..4631583 (-) Length 145 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGE25_RS22010 4626715..4627857 - 1143 WP_045511691.1 slipin family protein -
FGE25_RS22015 4628328..4629914 + 1587 WP_160271363.1 RNA repair transcriptional activator RtcR -
FGE25_RS22020 4630171..4631112 + 942 WP_020456092.1 ketopantoate/pantoate/pantothenate transporter PanS -
FGE25_RS22025 4631149..4631583 - 435 WP_045511685.1 helix-turn-helix domain-containing protein Antitoxin
FGE25_RS22030 4631580..4631891 - 312 WP_045511683.1 type II toxin-antitoxin system HigB family toxin Toxin
FGE25_RS22035 4632139..4632411 + 273 WP_017459411.1 DUF3811 domain-containing protein -
FGE25_RS22040 4632412..4633275 - 864 WP_045511681.1 23S rRNA pseudouridine(2604) synthase RluF -
FGE25_RS22045 4633415..4635046 - 1632 WP_160271364.1 Na/Pi cotransporter family protein -
FGE25_RS22050 4635218..4635685 - 468 WP_160271365.1 hypothetical protein -
FGE25_RS22055 4635669..4636445 - 777 WP_097406538.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12277.11 Da        Isoelectric Point: 9.3290

>T126485 WP_045511683.1 NZ_CP040677:c4631891-4631580 [Kosakonia sacchari]
MHVISRRPFDNAAKDFPNHTLALDAVYKILKSTVYQNPDALREEFPSLDKMIYRDKWWVINVGGNHLRVLFFADFESAKI
FVKHIVTHAEYDKLIRHYRETKE

Download         Length: 312 bp

>T126485 NZ_CP040677:c4631891-4631580 [Kosakonia sacchari]
ATGCACGTTATATCAAGGAGGCCGTTCGATAACGCGGCTAAAGATTTTCCAAACCACACGCTTGCGCTGGACGCGGTTTA
CAAAATCCTGAAAAGCACTGTTTACCAGAATCCAGACGCGTTGCGAGAAGAGTTCCCAAGCCTGGACAAGATGATATACA
GGGATAAATGGTGGGTTATCAATGTCGGTGGCAACCATTTGAGGGTGCTGTTTTTCGCAGACTTTGAATCAGCAAAAATA
TTTGTCAAACATATCGTGACCCATGCCGAGTATGACAAATTGATAAGACATTATCGGGAGACCAAAGAATGA

Antitoxin


Download         Length: 145 a.a.        Molecular weight: 15962.20 Da        Isoelectric Point: 5.5556

>AT126485 WP_045511685.1 NZ_CP040677:c4631583-4631149 [Kosakonia sacchari]
MIEDAIKAADELVKLVPFLGNNPGKEEYEQALEMVERLLMHAPDSSLAALLTAKIEHYENNDPELAAFNARIAALPRGVA
ALRVLMDQHGLNQSSFRDEIGQRSLVSRILNGERNLTVDHIRALAKRFNVSTDVFIEPAHHIAG

Download         Length: 435 bp

>AT126485 NZ_CP040677:c4631583-4631149 [Kosakonia sacchari]
ATGATTGAGGATGCGATCAAGGCTGCTGACGAGCTGGTGAAACTGGTGCCTTTTTTGGGAAATAACCCCGGCAAAGAGGA
GTATGAGCAAGCGCTGGAGATGGTTGAACGGTTGCTCATGCATGCGCCGGATAGCTCCCTGGCCGCGCTGCTTACCGCAA
AAATAGAGCACTATGAAAATAACGACCCGGAGCTGGCGGCGTTTAACGCGCGTATCGCGGCACTGCCACGCGGCGTTGCC
GCTTTACGGGTTTTGATGGATCAGCACGGATTAAATCAGTCTTCGTTTCGGGATGAAATCGGCCAGCGCTCCCTGGTGAG
CCGCATTCTTAATGGCGAACGCAATCTGACTGTCGACCATATCCGAGCGCTGGCGAAACGCTTTAATGTGTCGACCGACG
TGTTTATTGAGCCAGCCCATCACATCGCGGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References