Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1797793..1798453 Replicon chromosome
Accession NZ_CP040677
Organism Kosakonia sacchari strain DSM 107661

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FGE25_RS08515 Protein ID WP_174240571.1
Coordinates 1797793..1798146 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FGE25_RS08520 Protein ID WP_045510571.1
Coordinates 1798151..1798453 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGE25_RS08495 1793061..1793801 + 741 WP_160269587.1 adenosylcobinamide-GDP ribazoletransferase -
FGE25_RS08500 1793829..1794887 + 1059 WP_160269589.1 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase -
FGE25_RS08505 1794926..1795237 - 312 WP_020454244.1 helix-turn-helix domain-containing protein -
FGE25_RS08510 1795475..1797577 + 2103 WP_045510577.1 elongation factor G -
FGE25_RS08515 1797793..1798146 + 354 WP_174240571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGE25_RS08520 1798151..1798453 + 303 WP_045510571.1 helix-turn-helix transcriptional regulator Antitoxin
FGE25_RS08525 1798536..1799483 + 948 WP_160271483.1 L,D-transpeptidase -
FGE25_RS08530 1799626..1800651 + 1026 WP_045510566.1 LLM class flavin-dependent oxidoreductase -
FGE25_RS08535 1800840..1801316 + 477 WP_020454238.1 cold shock domain-containing protein -
FGE25_RS08540 1801570..1802109 + 540 WP_045510562.1 DUF2058 domain-containing protein -
FGE25_RS08545 1802147..1802392 + 246 WP_045510559.1 YmjA family protein -
FGE25_RS08550 1802490..1802996 - 507 WP_160269591.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13710.94 Da        Isoelectric Point: 10.2241

>T126474 WP_174240571.1 NZ_CP040677:1797793-1798146 [Kosakonia sacchari]
VWQIMMTQTFEKWFDALGDNDRARVLAALMVLRVKGPQLPRPYADTVKGSRYNNMKELRIQSRGEPFRVFYAFDPQRVGI
LLCAGNKASHEKRFYDVMIQIADRELTSHLHQLKIKE

Download         Length: 354 bp

>T126474 NZ_CP040677:1797793-1798146 [Kosakonia sacchari]
GTGTGGCAGATAATGATGACGCAGACGTTTGAAAAGTGGTTTGATGCACTGGGTGACAACGATCGCGCCCGTGTGCTGGC
GGCGCTGATGGTGCTACGGGTTAAAGGTCCGCAGCTACCAAGGCCTTACGCGGATACGGTAAAAGGCTCGCGTTATAACA
ATATGAAGGAGCTGCGCATACAAAGCCGGGGTGAGCCGTTTCGGGTCTTCTATGCCTTTGATCCGCAGCGCGTGGGCATA
TTGCTTTGTGCTGGCAACAAGGCGAGTCATGAAAAACGCTTTTACGATGTGATGATCCAGATTGCAGATCGGGAGCTAAC
GAGCCATCTGCACCAGCTTAAAATCAAGGAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11147.97 Da        Isoelectric Point: 7.2030

>AT126474 WP_045510571.1 NZ_CP040677:1798151-1798453 [Kosakonia sacchari]
MSKTLEQLIAEQKADVVTAAQSLAQEMLLNIHLAELRERVQKTQIEMAQALGLKQPTVAVMEKQGRDIKLSTLKRYVEAT
GSKLRIDIELPDGSHYGFAL

Download         Length: 303 bp

>AT126474 NZ_CP040677:1798151-1798453 [Kosakonia sacchari]
ATGAGCAAAACACTGGAACAGCTAATTGCCGAACAAAAGGCTGATGTTGTCACCGCTGCGCAGTCACTCGCGCAAGAGAT
GCTGCTCAATATCCATCTTGCGGAGCTGCGTGAGCGGGTACAAAAAACGCAGATCGAAATGGCGCAGGCGCTGGGGCTGA
AACAGCCCACGGTAGCGGTGATGGAAAAGCAGGGCCGGGATATTAAACTTTCCACGCTGAAGCGCTACGTGGAAGCGACA
GGCAGCAAGCTACGCATTGATATTGAGCTGCCGGATGGCTCCCACTATGGCTTTGCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References