Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1021816..1022465 Replicon chromosome
Accession NZ_CP040677
Organism Kosakonia sacchari strain DSM 107661

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FGE25_RS04915 Protein ID WP_097407336.1
Coordinates 1021816..1022178 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FGE25_RS04920 Protein ID WP_020454950.1
Coordinates 1022166..1022465 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGE25_RS04890 1017162..1018166 - 1005 WP_160268898.1 LacI family transcriptional regulator -
FGE25_RS04895 1018206..1020065 - 1860 WP_160268900.1 beta-glucoside-specific PTS transporter subunit IIABC -
FGE25_RS04900 1020297..1020611 + 315 WP_160268902.1 antibiotic biosynthesis monooxygenase -
FGE25_RS04905 1020613..1021005 + 393 WP_160268904.1 amino acid-binding protein -
FGE25_RS04910 1021002..1021709 + 708 WP_160271474.1 winged helix-turn-helix domain-containing protein -
FGE25_RS04915 1021816..1022178 + 363 WP_097407336.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGE25_RS04920 1022166..1022465 + 300 WP_020454950.1 helix-turn-helix domain-containing protein Antitoxin
FGE25_RS04925 1023057..1023824 + 768 WP_160268907.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -
FGE25_RS04930 1023808..1024860 + 1053 WP_160268909.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
FGE25_RS04935 1024934..1026760 - 1827 WP_160268912.1 glycoside hydrolase family 15 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-84)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14030.14 Da        Isoelectric Point: 8.8908

>T126473 WP_097407336.1 NZ_CP040677:1021816-1022178 [Kosakonia sacchari]
MWQVITTERFDVWFSIQPELLQDEVLAVFRILSEFGPQLGRPYVDTVKGSTYSNMKELRIQYAGSPVRAFFAFDSTRRGI
VLCAGDKTGVNEKRFYKEMIKIADAEFKNHMRNKELTWQP

Download         Length: 363 bp

>T126473 NZ_CP040677:1021816-1022178 [Kosakonia sacchari]
ATGTGGCAAGTGATTACGACGGAGCGTTTTGATGTGTGGTTTAGCATCCAGCCAGAACTGTTGCAGGATGAGGTTTTAGC
GGTTTTCAGGATCCTGAGTGAGTTTGGCCCGCAGCTTGGGCGCCCCTATGTTGATACTGTAAAAGGATCAACCTATAGCA
ATATGAAAGAGTTGAGGATCCAGTATGCAGGTTCTCCCGTTCGCGCCTTTTTTGCGTTCGATTCTACGCGGCGGGGTATT
GTGTTGTGCGCCGGAGATAAAACGGGCGTTAACGAGAAACGATTTTATAAAGAGATGATAAAAATTGCCGACGCAGAGTT
CAAAAATCATATGCGAAATAAGGAGTTAACGTGGCAACCTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10974.62 Da        Isoelectric Point: 8.6587

>AT126473 WP_020454950.1 NZ_CP040677:1022166-1022465 [Kosakonia sacchari]
VATLDDLLAKRSPESQARIEERVNELRRNIVLSQLREELNISQTELAGVMGVKQPTLAKIEQPGNDPRLSTLKRYVSALG
GELSIDITLPTGKRVAFHI

Download         Length: 300 bp

>AT126473 NZ_CP040677:1022166-1022465 [Kosakonia sacchari]
GTGGCAACCTTAGACGACCTTTTAGCGAAACGCAGCCCTGAAAGCCAGGCGCGAATTGAAGAGCGTGTTAATGAGCTGCG
CCGCAACATTGTATTGAGCCAGCTACGTGAAGAATTGAATATTTCCCAGACCGAGCTTGCCGGAGTCATGGGCGTCAAAC
AGCCGACACTGGCGAAGATAGAGCAGCCTGGCAACGATCCCCGTCTCTCTACTCTCAAGCGCTATGTCTCTGCGTTAGGC
GGTGAGTTAAGCATTGATATCACATTGCCGACGGGTAAACGCGTTGCATTTCATATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References