Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2505655..2505839 Replicon chromosome
Accession NZ_CP040665
Organism Staphylococcus aureus strain D592

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag FFX42_RS12800 Protein ID WP_000482652.1
Coordinates 2505732..2505839 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2505655..2505715 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFX42_RS12785 2501110..2501277 - 168 Protein_2413 hypothetical protein -
FFX42_RS12790 2501508..2503241 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
FFX42_RS12795 2503266..2505029 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2505655..2505715 + 61 - - Antitoxin
FFX42_RS12800 2505732..2505839 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
FFX42_RS12805 2505973..2506359 - 387 WP_000779360.1 flippase GtxA -
FFX42_RS12810 2506627..2507769 + 1143 WP_001176863.1 glycerate kinase -
FFX42_RS12815 2507829..2508488 + 660 WP_000831298.1 membrane protein -
FFX42_RS12820 2508670..2509881 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
FFX42_RS12825 2510004..2510477 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T126434 WP_000482652.1 NZ_CP040665:c2505839-2505732 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T126434 NZ_CP040665:c2505839-2505732 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT126434 NZ_CP040665:2505655-2505715 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References