Detailed information of TA system TA126427

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2048734..2049033
• Replicon: chromosome
• Accession: NZ_CP040665
• Organism: Staphylococcus aureus strain D592

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: FFX42_RS10315
• Protein ID: WP_011447039.1
• Coordinates: 2048857..2049033 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2048734..2048789 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFX42_RS10265	2044065..2044325	+	261	WP_001791826.1	hypothetical protein	-
FFX42_RS10270	2044378..2044728	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
FFX42_RS10275	2045413..2045862	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
FFX42_RS10280	2045957..2046292	-	336	Protein_1939	SH3 domain-containing protein	-
FFX42_RS10295	2046942..2047433	-	492	WP_000919350.1	staphylokinase	-
FFX42_RS10300	2047624..2048379	-	756	WP_000861038.1	CHAP domain-containing protein	-
FFX42_RS10305	2048391..2048645	-	255	WP_000611512.1	phage holin	-
FFX42_RS10310	2048697..2048804	+	108	WP_001791821.1	hypothetical protein	-
-	2048726..2048865	+	140	NuclAT_0	-	-
-	2048726..2048865	+	140	NuclAT_0	-	-
-	2048726..2048865	+	140	NuclAT_0	-	-
-	2048726..2048865	+	140	NuclAT_0	-	-
-	2048734..2048789	+	56	-	-	Antitoxin
FFX42_RS10315	2048857..2049033	-	177	WP_011447039.1	putative holin-like toxin	Toxin
FFX42_RS10320	2049183..2049479	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
FFX42_RS10325	2049537..2049824	-	288	WP_001040261.1	hypothetical protein	-
FFX42_RS10330	2049871..2050023	-	153	WP_001153681.1	hypothetical protein	-
FFX42_RS10335	2050013..2053798	-	3786	WP_000582154.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2044378..2094874	50496

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T126427 WP_011447039.1 NZ_CP040665:c2049033-2048857 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T126427 NZ_CP040665:c2049033-2048857 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT126427 NZ_CP040665:2048734-2048789 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin