Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2220772..2221274 Replicon chromosome
Accession NZ_CP040643
Organism Escherichia coli strain BE104

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag FGC38_RS11230 Protein ID WP_000767829.1
Coordinates 2220772..2221026 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag FGC38_RS11235 Protein ID WP_001259255.1
Coordinates 2221023..2221274 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGC38_RS11200 2215787..2216014 - 228 WP_000234896.1 sulfurtransferase TusA -
FGC38_RS11205 2216028..2217086 - 1059 WP_000492339.1 transport protein YeeE -
FGC38_RS11210 2217265..2218623 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
FGC38_RS11215 2218613..2218675 - 63 WP_010723108.1 membrane protein YoeI -
FGC38_RS11220 2218890..2219819 - 930 WP_000803351.1 LysR family transcriptional regulator -
FGC38_RS11225 2219865..2220689 - 825 WP_000754737.1 SDR family oxidoreductase -
FGC38_RS11230 2220772..2221026 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
FGC38_RS11235 2221023..2221274 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
FGC38_RS11240 2221557..2221607 + 51 WP_001364200.1 his operon leader peptide -
FGC38_RS11245 2221753..2222652 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
FGC38_RS11250 2222658..2223962 + 1305 WP_000009594.1 histidinol dehydrogenase -
FGC38_RS11255 2223959..2225029 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
FGC38_RS11260 2225029..2226096 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T126275 WP_000767829.1 NZ_CP040643:c2221026-2220772 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T126275 NZ_CP040643:c2221026-2220772 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT126275 WP_001259255.1 NZ_CP040643:c2221274-2221023 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT126275 NZ_CP040643:c2221274-2221023 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References