Detailed information of TA system TA126230

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3315122..3315801
• Replicon: chromosome
• Accession: NZ_CP040634
• Organism: Acidipropionibacterium acidipropionici strain FAM 19036

Toxin (Protein)

• Gene name: HigB2
• Uniprot ID: -
• Locus tag: FEZ30_RS15335
• Protein ID: WP_138574945.1
• Coordinates: 3315433..3315801 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: HigA2
• Uniprot ID: -
• Locus tag: FEZ30_RS15330
• Protein ID: WP_036937900.1
• Coordinates: 3315122..3315427 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEZ30_RS15300	3310484..3311776	-	1293	WP_175419171.1	ArsB/NhaD family transporter	-
FEZ30_RS15305	3311829..3312278	-	450	WP_062819792.1	CBS domain-containing protein	-
FEZ30_RS15310	3312508..3312774	+	267	WP_015068798.1	hypothetical protein	-
FEZ30_RS15315	3312932..3314149	-	1218	WP_138574941.1	DDE-type integrase/transposase/recombinase	-
FEZ30_RS15320	3314277..3314540	+	264	WP_015068797.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
FEZ30_RS15325	3314540..3314959	+	420	WP_138574943.1	type II toxin-antitoxin system VapC family toxin	-
FEZ30_RS15330	3315122..3315427	-	306	WP_036937900.1	helix-turn-helix domain-containing protein	Antitoxin
FEZ30_RS15335	3315433..3315801	-	369	WP_138574945.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FEZ30_RS15345	3316194..3317111	+	918	WP_138574947.1	SDR family oxidoreductase	-
FEZ30_RS15350	3317261..3317590	+	330	WP_062819789.1	PadR family transcriptional regulator	-
FEZ30_RS15355	3317590..3317997	+	408	WP_126133026.1	DUF1048 domain-containing protein	-
FEZ30_RS15360	3317994..3318797	+	804	WP_138574949.1	ATP-binding cassette domain-containing protein	-
FEZ30_RS15365	3318794..3319555	+	762	WP_138574951.1	ABC transporter permease	-
FEZ30_RS15370	3319573..3319956	-	384	WP_015068789.1	D-ribose pyranase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (18-113)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-88)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13940.03 Da
• Isoelectric Point: 9.4797

>T126230 WP_138574945.1 NZ_CP040634:c3315801-3315433 [Acidipropionibacterium acidipropionici]
MVYTCGVWDIDAELIESWVGSLDEASRAQVIAALRILREAGPQLGRPLVDTVKASRYKNMKELRPGSSGRSELRILFAFD
PVRRAILLVAGDKAGDWERWYRKNIPRADDLYEQHLADLKRK

Nucleotide

• Length: 369 bp

>T126230 NZ_CP040634:c3315801-3315433 [Acidipropionibacterium acidipropionici]
ATGGTCTATACTTGTGGTGTGTGGGATATCGACGCCGAGCTCATCGAATCCTGGGTGGGTTCCCTGGATGAGGCGTCGCG
GGCTCAGGTGATCGCCGCTCTCCGGATTCTCCGGGAGGCGGGTCCGCAACTCGGCCGCCCCCTCGTCGACACGGTGAAGG
CGTCCCGCTACAAGAACATGAAGGAGTTGCGCCCGGGCTCATCGGGACGATCGGAACTGAGAATCCTGTTCGCCTTCGAT
CCTGTCCGCAGAGCCATCCTCCTGGTAGCCGGCGACAAGGCTGGCGACTGGGAGCGCTGGTACCGCAAGAACATCCCAAG
AGCCGATGACCTGTACGAGCAGCACCTCGCAGACCTGAAACGGAAGTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11394.94 Da
• Isoelectric Point: 7.0164

>AT126230 WP_036937900.1 NZ_CP040634:c3315427-3315122 [Acidipropionibacterium acidipropionici]
MSLSLEDLEKRYPVDERLVRAAEDQMRAEVRAYKLRELRERAGLTQAQLAERIGVGQRQVSKIEHGDLDSAKLGTIRRYL
QAVGGDLAVEYVAGDQRLQVA

Nucleotide

• Length: 306 bp

>AT126230 NZ_CP040634:c3315427-3315122 [Acidipropionibacterium acidipropionici]
ATGAGCCTGTCTCTGGAGGATCTGGAGAAGAGGTACCCGGTCGATGAGCGACTCGTCCGGGCCGCCGAGGATCAGATGCG
CGCCGAGGTCCGCGCCTACAAGCTCCGCGAACTGCGTGAGCGCGCCGGGCTCACCCAGGCCCAACTGGCGGAACGAATCG
GCGTCGGACAGCGGCAGGTCTCCAAGATCGAACATGGCGACCTTGACAGCGCGAAACTCGGCACCATCCGCAGGTACCTC
CAAGCCGTCGGCGGTGACCTCGCCGTTGAGTACGTGGCTGGAGACCAGCGGCTACAAGTCGCCTGA