Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1995072..1995682 Replicon chromosome
Accession NZ_CP040634
Organism Acidipropionibacterium acidipropionici strain FAM 19036

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FEZ30_RS09295 Protein ID WP_138573710.1
Coordinates 1995072..1995353 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag FEZ30_RS09300 Protein ID WP_138573712.1
Coordinates 1995377..1995682 (+) Length 102 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEZ30_RS09275 1990366..1991499 - 1134 WP_062820489.1 glycosyltransferase -
FEZ30_RS09280 1991504..1991938 - 435 WP_062820488.1 RDD family protein -
FEZ30_RS09285 1991962..1993251 - 1290 WP_126132979.1 hypothetical protein -
FEZ30_RS09290 1993464..1994885 + 1422 WP_138573708.1 type I glutamate--ammonia ligase -
FEZ30_RS09295 1995072..1995353 + 282 WP_138573710.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FEZ30_RS09300 1995377..1995682 + 306 WP_138573712.1 HigA family addiction module antidote protein Antitoxin
FEZ30_RS09305 1996147..1997163 - 1017 WP_138573714.1 YdcF family protein -
FEZ30_RS09310 1997288..1998106 + 819 WP_138573716.1 Nif3-like dinuclear metal center hexameric protein -
FEZ30_RS09315 1998114..1999406 + 1293 WP_138573718.1 threonine/serine exporter family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-93)

Antitoxin

(8-83)


Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 10770.16 Da        Isoelectric Point: 9.9572

>T126228 WP_138573710.1 NZ_CP040634:1995072-1995353 [Acidipropionibacterium acidipropionici]
VIRSFKNTDTKKVWNREYVRAFGPELQRAAQKKLRLLNAASELNSLRVPPGNRLEKLVGGRDGQHSIRINDQYRICFVWT
DNGADDVEITDYH

Download         Length: 282 bp

>T126228 NZ_CP040634:1995072-1995353 [Acidipropionibacterium acidipropionici]
GTGATCCGGTCCTTCAAGAACACCGACACGAAGAAGGTCTGGAACCGCGAATATGTCCGCGCATTCGGACCCGAGCTGCA
ACGCGCCGCGCAGAAGAAGCTTCGCCTCCTCAACGCGGCCTCAGAACTGAACAGCCTTCGGGTGCCGCCGGGAAATCGCT
TGGAGAAGCTGGTCGGCGGCCGCGACGGCCAGCACTCCATCCGCATCAACGACCAGTACCGAATCTGCTTCGTGTGGACC
GACAACGGAGCAGACGACGTCGAGATCACCGACTATCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11170.71 Da        Isoelectric Point: 4.8182

>AT126228 WP_138573712.1 NZ_CP040634:1995377-1995682 [Acidipropionibacterium acidipropionici]
MATASKAHDPITPGEILLTEFLEPMGITQYRLAQATGLSQTRISEIVRGKRAITTDTALRLSKALGVDDRFWINIQTDYD
LEVERDLHGDELAKVTTLVAS

Download         Length: 306 bp

>AT126228 NZ_CP040634:1995377-1995682 [Acidipropionibacterium acidipropionici]
ATGGCGACAGCATCGAAGGCACACGACCCGATCACTCCCGGTGAGATCCTGCTGACTGAGTTTCTTGAGCCGATGGGCAT
CACGCAGTACCGCCTCGCCCAGGCCACTGGACTCTCCCAGACCCGGATCAGCGAGATCGTGCGCGGCAAGCGCGCCATCA
CCACCGATACCGCCCTCCGGCTGTCCAAGGCCCTCGGGGTCGACGACCGCTTCTGGATCAACATCCAGACCGACTACGAC
CTCGAGGTCGAGCGCGACCTGCACGGCGACGAACTGGCCAAGGTGACCACCCTGGTCGCGAGCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References