126226

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/-
Location 2795552..2796215 Replicon chromosome
Accession NZ_CP040630
Organism Bacteroides sp. PHL 2737

Toxin (Protein)


Gene name HipT Uniprot ID A0A4Q0U3J6
Locus tag DBK98_RS11425 Protein ID WP_032536341.1
Coordinates 2795880..2796215 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A4Q0U0V4
Locus tag DBK98_RS11420 Protein ID WP_032536342.1
Coordinates 2795552..2795878 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBK98_RS11390 2790714..2791757 + 1044 WP_032536360.1 glycosyltransferase family 4 protein -
DBK98_RS11395 2791770..2792594 + 825 WP_022011505.1 glycosyltransferase family 2 protein -
DBK98_RS11400 2792603..2793499 + 897 WP_032536359.1 NAD-dependent epimerase/dehydratase family protein -
DBK98_RS11405 2793615..2794565 + 951 WP_032536345.1 glycosyltransferase family 4 protein -
DBK98_RS11410 2794568..2795155 + 588 WP_032536344.1 N-acetylmuramidase family protein -
DBK98_RS11415 2795340..2795555 + 216 WP_032536343.1 helix-turn-helix transcriptional regulator -
DBK98_RS11420 2795552..2795878 + 327 WP_032536342.1 HipA N-terminal domain-containing protein Antitoxin
DBK98_RS11425 2795880..2796215 + 336 WP_032536341.1 HipA domain-containing protein Toxin
DBK98_RS11430 2796263..2797837 - 1575 WP_032531836.1 Rne/Rng family ribonuclease -
DBK98_RS11435 2798117..2798392 - 276 WP_005776335.1 integration host factor subunit beta -
DBK98_RS11440 2798597..2799643 + 1047 WP_032536340.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(1-82)

Antitoxin

HipA, N-terminal subdomain 1

(3-97)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13038.10 Da        Isoelectric Point: 9.2916

>T126226 WP_032536341.1 NZ_CP040630:2795880-2796215 [Bacteroides sp. PHL 2737]
MHLKNFSLYSTKPISYVLTPAYDLLSTKLVLPADSEELALTLNGKKKKIKKSDFVVAMNSTGLEDKIIENVFNKFDHLQS
KWEEFIDVSFIQETTKERYKELIHENWKRIK

Download         Length: 336 bp

>T126226 NZ_CP040630:2795880-2796215 [Bacteroides sp. PHL 2737]
ATGCATTTGAAGAACTTTTCTTTATATAGTACGAAACCTATTAGTTATGTTCTGACACCCGCTTATGACTTACTGTCAAC
GAAGTTAGTCCTTCCTGCCGATTCTGAGGAATTGGCATTAACACTTAATGGGAAGAAGAAGAAAATAAAGAAGTCGGACT
TTGTTGTTGCAATGAACTCGACCGGCTTGGAAGATAAGATTATTGAAAATGTTTTTAATAAGTTTGATCACCTTCAGTCT
AAATGGGAAGAGTTTATAGATGTTTCTTTTATACAAGAAACAACCAAAGAAAGGTATAAGGAGCTTATACATGAAAATTG
GAAAAGGATTAAGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12203.00 Da        Isoelectric Point: 4.4217

>AT126226 WP_032536342.1 NZ_CP040630:2795552-2795878 [Bacteroides sp. PHL 2737]
MKKAEIYVSNQLAGILIEDENGFSFTYTDEYISKGNRRPVSLTLPITHVPYTSSVLFPFFNGLIPEGWLLDIAEQSWKIS
SRDRMALLLACCKDCIGDSTLLLDYGEF

Download         Length: 327 bp

>AT126226 NZ_CP040630:2795552-2795878 [Bacteroides sp. PHL 2737]
ATGAAAAAGGCTGAAATTTATGTTAGCAATCAGTTAGCCGGTATTTTGATTGAAGATGAAAATGGCTTTTCTTTCACTTA
TACAGACGAATATATTTCAAAGGGAAACCGACGACCTGTTAGTCTGACGCTTCCGATAACTCATGTCCCTTATACAAGCT
CTGTGCTGTTTCCTTTTTTTAATGGATTAATTCCTGAAGGATGGTTGCTTGATATTGCGGAACAAAGTTGGAAGATAAGT
AGTCGGGATAGAATGGCTTTGCTGCTGGCTTGTTGTAAGGATTGCATAGGAGATAGTACTCTTCTCTTGGATTACGGGGA
ATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q0U3J6

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q0U0V4

References