Detailed information of TA system TA126218

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2309568..2309847
• Replicon: chromosome
• Accession: NZ_CP040625
• Organism: Staphylococcus aureus strain JKD6004-DR

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: FF960_RS11900
• Protein ID: WP_001802298.1
• Coordinates: 2309743..2309847 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2309568..2309747 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF960_RS11880	2305767..2306432	-	666	WP_001024094.1	SDR family oxidoreductase	-
FF960_RS11885	2306584..2306904	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
FF960_RS11890	2306906..2307886	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
FF960_RS11895	2308152..2309243	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2309568..2309747	+	180	-	-	Antitoxin
FF960_RS11900	2309743..2309847	-	105	WP_001802298.1	hypothetical protein	Toxin
FF960_RS11905	2310008..2310491	-	484	Protein_2243	recombinase family protein	-
FF960_RS11910	2310534..2311670	-	1137	WP_000115564.1	SAP domain-containing protein	-
FF960_RS11915	2311959..2312051	+	93	WP_001790138.1	hypothetical protein	-
FF960_RS11920	2312756..2313613	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
FF960_RS11925	2313681..2314463	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T126218 WP_001802298.1 NZ_CP040625:c2309847-2309743 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T126218 NZ_CP040625:c2309847-2309743 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT126218 NZ_CP040625:2309568-2309747 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin