Detailed information of TA system TA126212

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2132740..2133039
• Replicon: chromosome
• Accession: NZ_CP040625
• Organism: Staphylococcus aureus strain JKD6004-DR

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: FF960_RS10895
• Protein ID: WP_072482930.1
• Coordinates: 2132863..2133039 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2132740..2132795 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF960_RS10840	2128298..2128477	+	180	WP_000669789.1	hypothetical protein	-
FF960_RS10850	2128788..2129048	+	261	WP_001791826.1	hypothetical protein	-
FF960_RS10855	2129101..2129451	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
FF960_RS10860	2129961..2130296	-	336	Protein_2045	SH3 domain-containing protein	-
FF960_RS10875	2130948..2131439	-	492	WP_000920041.1	staphylokinase	-
FF960_RS10880	2131630..2132385	-	756	WP_138663901.1	CHAP domain-containing protein	-
FF960_RS10885	2132397..2132651	-	255	WP_000611512.1	phage holin	-
FF960_RS10890	2132703..2132810	+	108	Protein_2049	hypothetical protein	-
-	2132732..2132871	+	140	NuclAT_0	-	-
-	2132732..2132871	+	140	NuclAT_0	-	-
-	2132732..2132871	+	140	NuclAT_0	-	-
-	2132732..2132871	+	140	NuclAT_0	-	-
-	2132740..2132795	+	56	-	-	Antitoxin
FF960_RS10895	2132863..2133039	-	177	WP_072482930.1	putative holin-like toxin	Toxin
FF960_RS10900	2133148..2133921	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
FF960_RS10905	2134294..2134668	-	375	WP_000340977.1	hypothetical protein	-
FF960_RS10910	2134724..2135011	-	288	WP_001262621.1	hypothetical protein	-
FF960_RS10915	2135057..2135209	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb	2126979..2176900	49921
	-	flank	IS/Tn	-	-	2126979..2128151	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T126212 WP_072482930.1 NZ_CP040625:c2133039-2132863 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T126212 NZ_CP040625:c2133039-2132863 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT126212 NZ_CP040625:2132740-2132795 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin