Detailed information of TA system TA126192

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1894460..1894640
• Replicon: chromosome
• Accession: NZ_CP040623
• Organism: Staphylococcus aureus strain D592-HR

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: FF959_RS09310
• Protein ID: WP_001801861.1
• Coordinates: 1894460..1894555 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1894583..1894640 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF959_RS09280	1889623..1890273	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
FF959_RS09285	1890354..1891349	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
FF959_RS09290	1891424..1892050	+	627	WP_000669024.1	hypothetical protein	-
FF959_RS09295	1892091..1892432	+	342	WP_000627540.1	DUF3969 family protein	-
FF959_RS09300	1892533..1893105	+	573	WP_000414216.1	hypothetical protein	-
FF959_RS09305	1893303..1894315	-	1013	Protein_1785	IS3 family transposase	-
FF959_RS09310	1894460..1894555	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1894583..1894640	-	58	-	-	Antitoxin
FF959_RS09315	1894678..1894779	+	102	WP_001792025.1	hypothetical protein	-
FF959_RS09320	1894757..1894918	-	162	Protein_1788	transposase	-
FF959_RS09325	1894909..1895403	-	495	Protein_1789	transposase	-
FF959_RS09330	1895855..1897084	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
FF959_RS09335	1897077..1898633	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
FF959_RS09340	1898797..1898931	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1870442..1921473	51031

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T126192 WP_001801861.1 NZ_CP040623:1894460-1894555 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T126192 NZ_CP040623:1894460-1894555 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT126192 NZ_CP040623:c1894640-1894583 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin