Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2599940..2600124 Replicon chromosome
Accession NZ_CP040622
Organism Staphylococcus aureus strain JKD6004

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag FF958_RS13445 Protein ID WP_000482650.1
Coordinates 2600017..2600124 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2599940..2600000 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF958_RS13430 2595470..2595637 - 168 WP_001790576.1 hypothetical protein -
FF958_RS13435 2595868..2597601 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
FF958_RS13440 2597626..2599389 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2599940..2600000 + 61 - - Antitoxin
FF958_RS13445 2600017..2600124 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
FF958_RS13450 2600257..2600643 - 387 WP_000779358.1 flippase GtxA -
FF958_RS13455 2600911..2602053 + 1143 WP_001176863.1 glycerate kinase -
FF958_RS13460 2602113..2602772 + 660 WP_000831298.1 membrane protein -
FF958_RS13465 2602954..2604165 + 1212 WP_138663906.1 multidrug effflux MFS transporter -
FF958_RS13470 2604288..2604761 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T126188 WP_000482650.1 NZ_CP040622:c2600124-2600017 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T126188 NZ_CP040622:c2600124-2600017 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT126188 NZ_CP040622:2599940-2600000 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References