Detailed information of TA system TA126177

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2131352..2131651
• Replicon: chromosome
• Accession: NZ_CP040622
• Organism: Staphylococcus aureus strain JKD6004

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: FF958_RS10905
• Protein ID: WP_072482930.1
• Coordinates: 2131475..2131651 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2131352..2131407 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF958_RS10850	2126910..2127089	+	180	WP_000669789.1	hypothetical protein	-
FF958_RS10860	2127400..2127660	+	261	WP_001791826.1	hypothetical protein	-
FF958_RS10865	2127713..2128063	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
FF958_RS10870	2128573..2128908	-	336	Protein_2046	SH3 domain-containing protein	-
FF958_RS10885	2129560..2130051	-	492	WP_000920041.1	staphylokinase	-
FF958_RS10890	2130242..2130997	-	756	WP_138663901.1	CHAP domain-containing protein	-
FF958_RS10895	2131009..2131263	-	255	WP_000611512.1	phage holin	-
FF958_RS10900	2131315..2131422	+	108	Protein_2050	hypothetical protein	-
-	2131344..2131483	+	140	NuclAT_0	-	-
-	2131344..2131483	+	140	NuclAT_0	-	-
-	2131344..2131483	+	140	NuclAT_0	-	-
-	2131344..2131483	+	140	NuclAT_0	-	-
-	2131352..2131407	+	56	-	-	Antitoxin
FF958_RS10905	2131475..2131651	-	177	WP_072482930.1	putative holin-like toxin	Toxin
FF958_RS10910	2131760..2132533	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
FF958_RS10915	2132906..2133280	-	375	WP_000340977.1	hypothetical protein	-
FF958_RS10920	2133336..2133623	-	288	WP_001262621.1	hypothetical protein	-
FF958_RS10925	2133669..2133821	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / sak / sea / hlb / groEL	2122565..2184918	62353
	-	flank	IS/Tn	-	-	2125591..2126763	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T126177 WP_072482930.1 NZ_CP040622:c2131651-2131475 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T126177 NZ_CP040622:c2131651-2131475 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT126177 NZ_CP040622:2131352-2131407 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin