Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2585289..2585812 Replicon chromosome
Accession NZ_CP040619
Organism Staphylococcus aureus strain J01

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag FF957_RS13400 Protein ID WP_000074048.1
Coordinates 2585289..2585555 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag FF957_RS13405 Protein ID WP_000587616.1
Coordinates 2585555..2585812 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF957_RS13380 2580596..2581783 - 1188 WP_000026194.1 MFS transporter -
FF957_RS13385 2582179..2582955 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
FF957_RS13390 2582948..2583610 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
FF957_RS13395 2583858..2584934 - 1077 WP_001076686.1 M42 family metallopeptidase -
FF957_RS13400 2585289..2585555 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
FF957_RS13405 2585555..2585812 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FF957_RS13410 2585918..2586112 - 195 WP_001790145.1 hypothetical protein -
FF957_RS13415 2586171..2586626 + 456 WP_000732082.1 DUF1307 domain-containing protein -
FF957_RS13420 2586794..2588371 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
FF957_RS13425 2588566..2589315 + 750 WP_000072443.1 hypothetical protein -
FF957_RS13430 2589539..2590732 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T126170 WP_000074048.1 NZ_CP040619:c2585555-2585289 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T126170 NZ_CP040619:c2585555-2585289 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT126170 WP_000587616.1 NZ_CP040619:c2585812-2585555 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT126170 NZ_CP040619:c2585812-2585555 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References