Detailed information of TA system TA126159

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2088824..2089123
• Replicon: chromosome
• Accession: NZ_CP040619
• Organism: Staphylococcus aureus strain J01

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: FF957_RS10725
• Protein ID: WP_011447039.1
• Coordinates: 2088947..2089123 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2088824..2088879 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF957_RS10680	2084155..2084415	+	261	WP_001791826.1	hypothetical protein	-
FF957_RS10685	2084468..2084818	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
FF957_RS10690	2085503..2085952	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
FF957_RS10695	2086047..2086382	-	336	Protein_2013	SH3 domain-containing protein	-
FF957_RS10705	2087032..2087523	-	492	WP_000919350.1	staphylokinase	-
FF957_RS10710	2087714..2088469	-	756	WP_000861038.1	CHAP domain-containing protein	-
FF957_RS10715	2088481..2088735	-	255	WP_000611512.1	phage holin	-
FF957_RS10720	2088787..2088894	+	108	WP_001791821.1	hypothetical protein	-
-	2088816..2088955	+	140	NuclAT_0	-	-
-	2088816..2088955	+	140	NuclAT_0	-	-
-	2088816..2088955	+	140	NuclAT_0	-	-
-	2088816..2088955	+	140	NuclAT_0	-	-
-	2088824..2088879	+	56	-	-	Antitoxin
FF957_RS10725	2088947..2089123	-	177	WP_011447039.1	putative holin-like toxin	Toxin
FF957_RS10730	2089273..2089569	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
FF957_RS10735	2089627..2089914	-	288	WP_001040261.1	hypothetical protein	-
FF957_RS10740	2089961..2090113	-	153	WP_001153681.1	hypothetical protein	-
FF957_RS10745	2090103..2093888	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2084468..2143474	59006

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T126159 WP_011447039.1 NZ_CP040619:c2089123-2088947 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T126159 NZ_CP040619:c2089123-2088947 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT126159 NZ_CP040619:2088824-2088879 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin