Detailed information of TA system TA126141

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 4027850..4028358
• Replicon: chromosome
• Accession: NZ_CP040605
• Organism: Saccharopolyspora sp. ASAGF58

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: FDZ84_RS19285
• Protein ID: WP_168587048.1
• Coordinates: 4027850..4028110 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: FDZ84_RS19290
• Protein ID: WP_093271697.1
• Coordinates: 4028107..4028358 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDZ84_RS19270	4026547..4026780	-	234	WP_168587045.1	hypothetical protein	-
FDZ84_RS19275	4026935..4027321	-	387	WP_168587046.1	XRE family transcriptional regulator	-
FDZ84_RS19280	4027325..4027672	-	348	WP_168587047.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FDZ84_RS19285	4027850..4028110	-	261	WP_168587048.1	Txe/YoeB family addiction module toxin	Toxin
FDZ84_RS19290	4028107..4028358	-	252	WP_093271697.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FDZ84_RS19295	4028431..4029189	-	759	WP_168587049.1	sirohydrochlorin chelatase	-
FDZ84_RS19300	4029197..4030483	-	1287	WP_168590183.1	50S ribosome-binding GTPase	-
FDZ84_RS19305	4030898..4031833	-	936	WP_168587050.1	sulfate adenylyltransferase subunit 2	-
FDZ84_RS19310	4031851..4032576	-	726	WP_168587051.1	phosphoadenylyl-sulfate reductase	-
FDZ84_RS19315	4032573..4032752	-	180	WP_168587052.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10217.73 Da
• Isoelectric Point: 9.4337

>T126141 WP_168587048.1 NZ_CP040605:c4028110-4027850 [Saccharopolyspora sp. ASAGF58]
MKLVWDGLAWDDYVWWQAEDRKILKRINALIKDICRNGNEGIGKPEPLKHGFQGYWSRRISDEHRLVYKVAGDEIRIAAC
RYHYGK

Nucleotide

• Length: 261 bp

>T126141 NZ_CP040605:c4028110-4027850 [Saccharopolyspora sp. ASAGF58]
ATGAAACTGGTCTGGGACGGGCTTGCCTGGGACGACTACGTCTGGTGGCAAGCCGAGGACCGCAAGATCCTCAAGCGAAT
CAACGCGCTGATCAAAGACATCTGCCGCAACGGGAACGAAGGAATCGGCAAACCCGAACCGCTCAAGCACGGTTTCCAGG
GCTACTGGTCGCGTCGCATCTCTGACGAGCATCGTCTGGTCTACAAGGTTGCGGGAGACGAGATTCGAATCGCGGCTTGC
CGCTACCACTACGGCAAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9335.44 Da
• Isoelectric Point: 4.5431

>AT126141 WP_093271697.1 NZ_CP040605:c4028358-4028107 [Saccharopolyspora sp. ASAGF58]
VKTMSYSESRAKYAETLDSVVNDREEVVITRAGHEPVVMVSLDDYQSLKETAYLLRSPENARRLILAIERLEAGGGEQHE
LAE

Nucleotide

• Length: 252 bp

>AT126141 NZ_CP040605:c4028358-4028107 [Saccharopolyspora sp. ASAGF58]
GTGAAGACGATGAGCTACTCCGAGTCCCGTGCCAAGTACGCCGAGACGCTCGACTCCGTGGTGAACGACCGCGAGGAAGT
CGTGATCACCCGAGCAGGGCACGAGCCCGTCGTGATGGTGTCATTGGATGACTACCAGTCCCTGAAGGAAACTGCCTACC
TGCTCCGCAGCCCCGAGAACGCCCGCCGCCTGATCCTCGCGATCGAGCGACTGGAAGCCGGCGGCGGAGAACAACACGAG
CTCGCCGAATGA