Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4027850..4028358 Replicon chromosome
Accession NZ_CP040605
Organism Saccharopolyspora sp. ASAGF58

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag FDZ84_RS19285 Protein ID WP_168587048.1
Coordinates 4027850..4028110 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag FDZ84_RS19290 Protein ID WP_093271697.1
Coordinates 4028107..4028358 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDZ84_RS19270 4026547..4026780 - 234 WP_168587045.1 hypothetical protein -
FDZ84_RS19275 4026935..4027321 - 387 WP_168587046.1 XRE family transcriptional regulator -
FDZ84_RS19280 4027325..4027672 - 348 WP_168587047.1 type II toxin-antitoxin system RelE/ParE family toxin -
FDZ84_RS19285 4027850..4028110 - 261 WP_168587048.1 Txe/YoeB family addiction module toxin Toxin
FDZ84_RS19290 4028107..4028358 - 252 WP_093271697.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FDZ84_RS19295 4028431..4029189 - 759 WP_168587049.1 sirohydrochlorin chelatase -
FDZ84_RS19300 4029197..4030483 - 1287 WP_168590183.1 50S ribosome-binding GTPase -
FDZ84_RS19305 4030898..4031833 - 936 WP_168587050.1 sulfate adenylyltransferase subunit 2 -
FDZ84_RS19310 4031851..4032576 - 726 WP_168587051.1 phosphoadenylyl-sulfate reductase -
FDZ84_RS19315 4032573..4032752 - 180 WP_168587052.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10217.73 Da        Isoelectric Point: 9.4337

>T126141 WP_168587048.1 NZ_CP040605:c4028110-4027850 [Saccharopolyspora sp. ASAGF58]
MKLVWDGLAWDDYVWWQAEDRKILKRINALIKDICRNGNEGIGKPEPLKHGFQGYWSRRISDEHRLVYKVAGDEIRIAAC
RYHYGK

Download         Length: 261 bp

>T126141 NZ_CP040605:c4028110-4027850 [Saccharopolyspora sp. ASAGF58]
ATGAAACTGGTCTGGGACGGGCTTGCCTGGGACGACTACGTCTGGTGGCAAGCCGAGGACCGCAAGATCCTCAAGCGAAT
CAACGCGCTGATCAAAGACATCTGCCGCAACGGGAACGAAGGAATCGGCAAACCCGAACCGCTCAAGCACGGTTTCCAGG
GCTACTGGTCGCGTCGCATCTCTGACGAGCATCGTCTGGTCTACAAGGTTGCGGGAGACGAGATTCGAATCGCGGCTTGC
CGCTACCACTACGGCAAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9335.44 Da        Isoelectric Point: 4.5431

>AT126141 WP_093271697.1 NZ_CP040605:c4028358-4028107 [Saccharopolyspora sp. ASAGF58]
VKTMSYSESRAKYAETLDSVVNDREEVVITRAGHEPVVMVSLDDYQSLKETAYLLRSPENARRLILAIERLEAGGGEQHE
LAE

Download         Length: 252 bp

>AT126141 NZ_CP040605:c4028358-4028107 [Saccharopolyspora sp. ASAGF58]
GTGAAGACGATGAGCTACTCCGAGTCCCGTGCCAAGTACGCCGAGACGCTCGACTCCGTGGTGAACGACCGCGAGGAAGT
CGTGATCACCCGAGCAGGGCACGAGCCCGTCGTGATGGTGTCATTGGATGACTACCAGTCCCTGAAGGAAACTGCCTACC
TGCTCCGCAGCCCCGAGAACGCCCGCCGCCTGATCCTCGCGATCGAGCGACTGGAAGCCGGCGGCGGAGAACAACACGAG
CTCGCCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References