Detailed information of TA system TA126140

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 4026935..4027672
• Replicon: chromosome
• Accession: NZ_CP040605
• Organism: Saccharopolyspora sp. ASAGF58

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FDZ84_RS19280
• Protein ID: WP_168587047.1
• Coordinates: 4027325..4027672 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FDZ84_RS19275
• Protein ID: WP_168587046.1
• Coordinates: 4026935..4027321 (-)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDZ84_RS19265	4022660..4026313	-	3654	WP_168587044.1	type VII secretion system-associated protein	-
FDZ84_RS19270	4026547..4026780	-	234	WP_168587045.1	hypothetical protein	-
FDZ84_RS19275	4026935..4027321	-	387	WP_168587046.1	XRE family transcriptional regulator	Antitoxin
FDZ84_RS19280	4027325..4027672	-	348	WP_168587047.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FDZ84_RS19285	4027850..4028110	-	261	WP_168587048.1	Txe/YoeB family addiction module toxin	-
FDZ84_RS19290	4028107..4028358	-	252	WP_093271697.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
FDZ84_RS19295	4028431..4029189	-	759	WP_168587049.1	sirohydrochlorin chelatase	-
FDZ84_RS19300	4029197..4030483	-	1287	WP_168590183.1	50S ribosome-binding GTPase	-
FDZ84_RS19305	4030898..4031833	-	936	WP_168587050.1	sulfate adenylyltransferase subunit 2	-
FDZ84_RS19310	4031851..4032576	-	726	WP_168587051.1	phosphoadenylyl-sulfate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (40-92)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13169.92 Da
• Isoelectric Point: 5.6306

>T126140 WP_168587047.1 NZ_CP040605:c4027672-4027325 [Saccharopolyspora sp. ASAGF58]
MHEEVNTWFFSLVQNDPESADLVEQALDLLAHQGPRLGRPLVDKIKGSRYHNLKELRPASAGRSEIRMLFAFDPRRCAIV
LVAGDKAGNWRGWYETNIPLAEKRFEEHLAELEEG

Nucleotide

• Length: 348 bp

>T126140 NZ_CP040605:c4027672-4027325 [Saccharopolyspora sp. ASAGF58]
TTGCACGAAGAGGTCAACACCTGGTTCTTCTCGTTGGTCCAGAACGACCCCGAGAGCGCCGACCTGGTCGAACAGGCACT
CGACCTGTTAGCCCACCAGGGGCCGCGGCTCGGACGTCCACTCGTAGACAAGATTAAGGGGTCTCGATACCACAATCTCA
AGGAACTACGTCCCGCTTCGGCGGGCAGGAGCGAGATCAGGATGTTGTTCGCCTTCGACCCACGACGTTGTGCCATTGTT
CTGGTGGCGGGCGACAAGGCCGGGAACTGGCGGGGTTGGTACGAGACGAACATCCCGCTTGCCGAGAAGCGTTTCGAGGA
ACACCTGGCGGAGTTAGAGGAGGGCTGA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 14164.94 Da
• Isoelectric Point: 5.3098

>AT126140 WP_168587046.1 NZ_CP040605:c4027321-4026935 [Saccharopolyspora sp. ASAGF58]
MGRSWKDAKKDKEALDRARGRDVEAAREQARILTQAYILGDRLAQLRKAAGLSQSEVAARMQVSQPRVSKLEQGNLAQIE
VGTLERYVAALGGRLKLVADFEDHDVTVSMNELDHSEDELDCTEKAGV

Nucleotide

• Length: 387 bp

>AT126140 NZ_CP040605:c4027321-4026935 [Saccharopolyspora sp. ASAGF58]
ATGGGTCGTTCCTGGAAGGACGCTAAGAAGGACAAGGAAGCCCTGGACCGGGCGCGTGGCCGCGATGTGGAAGCCGCCAG
GGAACAAGCCCGCATCCTCACCCAGGCCTACATTCTGGGCGACCGCCTCGCCCAGCTGCGCAAAGCGGCCGGACTGTCAC
AGTCGGAGGTCGCCGCGCGGATGCAGGTCAGCCAGCCCCGCGTGAGCAAACTCGAACAGGGGAACTTGGCGCAGATCGAG
GTCGGCACGCTTGAGCGCTACGTCGCTGCCCTCGGGGGACGCCTCAAACTCGTAGCGGACTTCGAAGATCACGATGTCAC
CGTCTCGATGAACGAGCTCGACCACTCCGAAGACGAACTCGACTGCACCGAAAAGGCGGGCGTCTGA