Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4026935..4027672 Replicon chromosome
Accession NZ_CP040605
Organism Saccharopolyspora sp. ASAGF58

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FDZ84_RS19280 Protein ID WP_168587047.1
Coordinates 4027325..4027672 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FDZ84_RS19275 Protein ID WP_168587046.1
Coordinates 4026935..4027321 (-) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDZ84_RS19265 4022660..4026313 - 3654 WP_168587044.1 type VII secretion system-associated protein -
FDZ84_RS19270 4026547..4026780 - 234 WP_168587045.1 hypothetical protein -
FDZ84_RS19275 4026935..4027321 - 387 WP_168587046.1 XRE family transcriptional regulator Antitoxin
FDZ84_RS19280 4027325..4027672 - 348 WP_168587047.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FDZ84_RS19285 4027850..4028110 - 261 WP_168587048.1 Txe/YoeB family addiction module toxin -
FDZ84_RS19290 4028107..4028358 - 252 WP_093271697.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
FDZ84_RS19295 4028431..4029189 - 759 WP_168587049.1 sirohydrochlorin chelatase -
FDZ84_RS19300 4029197..4030483 - 1287 WP_168590183.1 50S ribosome-binding GTPase -
FDZ84_RS19305 4030898..4031833 - 936 WP_168587050.1 sulfate adenylyltransferase subunit 2 -
FDZ84_RS19310 4031851..4032576 - 726 WP_168587051.1 phosphoadenylyl-sulfate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13169.92 Da        Isoelectric Point: 5.6306

>T126140 WP_168587047.1 NZ_CP040605:c4027672-4027325 [Saccharopolyspora sp. ASAGF58]
MHEEVNTWFFSLVQNDPESADLVEQALDLLAHQGPRLGRPLVDKIKGSRYHNLKELRPASAGRSEIRMLFAFDPRRCAIV
LVAGDKAGNWRGWYETNIPLAEKRFEEHLAELEEG

Download         Length: 348 bp

>T126140 NZ_CP040605:c4027672-4027325 [Saccharopolyspora sp. ASAGF58]
TTGCACGAAGAGGTCAACACCTGGTTCTTCTCGTTGGTCCAGAACGACCCCGAGAGCGCCGACCTGGTCGAACAGGCACT
CGACCTGTTAGCCCACCAGGGGCCGCGGCTCGGACGTCCACTCGTAGACAAGATTAAGGGGTCTCGATACCACAATCTCA
AGGAACTACGTCCCGCTTCGGCGGGCAGGAGCGAGATCAGGATGTTGTTCGCCTTCGACCCACGACGTTGTGCCATTGTT
CTGGTGGCGGGCGACAAGGCCGGGAACTGGCGGGGTTGGTACGAGACGAACATCCCGCTTGCCGAGAAGCGTTTCGAGGA
ACACCTGGCGGAGTTAGAGGAGGGCTGA

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 14164.94 Da        Isoelectric Point: 5.3098

>AT126140 WP_168587046.1 NZ_CP040605:c4027321-4026935 [Saccharopolyspora sp. ASAGF58]
MGRSWKDAKKDKEALDRARGRDVEAAREQARILTQAYILGDRLAQLRKAAGLSQSEVAARMQVSQPRVSKLEQGNLAQIE
VGTLERYVAALGGRLKLVADFEDHDVTVSMNELDHSEDELDCTEKAGV

Download         Length: 387 bp

>AT126140 NZ_CP040605:c4027321-4026935 [Saccharopolyspora sp. ASAGF58]
ATGGGTCGTTCCTGGAAGGACGCTAAGAAGGACAAGGAAGCCCTGGACCGGGCGCGTGGCCGCGATGTGGAAGCCGCCAG
GGAACAAGCCCGCATCCTCACCCAGGCCTACATTCTGGGCGACCGCCTCGCCCAGCTGCGCAAAGCGGCCGGACTGTCAC
AGTCGGAGGTCGCCGCGCGGATGCAGGTCAGCCAGCCCCGCGTGAGCAAACTCGAACAGGGGAACTTGGCGCAGATCGAG
GTCGGCACGCTTGAGCGCTACGTCGCTGCCCTCGGGGGACGCCTCAAACTCGTAGCGGACTTCGAAGATCACGATGTCAC
CGTCTCGATGAACGAGCTCGACCACTCCGAAGACGAACTCGACTGCACCGAAAAGGCGGGCGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References